Increased pancreatic-derived factor (PANDER) levels in gestational diabetes mellitus

Abstract

The aim of the study was to investigate the pancreatic-derived factor (PANDER) levels in healthy pregnant women and in pregnant women with gestational diabetes mellitus (GDM). A total of 50 women consecutively diagnosed with GDM and 30 randomly selected age-matched and gestational-age-matched healthy pregnant women were included in this cross-sectional study. Serum PANDER levels and other variables were analyzed. The age, the gestational age at the time, the blood sample was obtained and the hemoglobin A1c (HbA1c) levels of the GDM and control groups were similar. The body mass index (BMI), fasting blood glucose, insulin, homeostasis model assessment of insulin resistance (HOMA-IR), and serum PANDER levels were significantly higher in the GDM group than the control group. The optimal PANDER cutoff value was 227.2 ng/ml, and the ratios above this value were 100 and 86.6% for sensitivity and specificity, respectively (p=.0001). Serum PANDER levels were higher in women with GDM compared to the control group and were positively correlated with insulin, HOMA-IR, and HbA1c levels. These results suggest that PANDER might be considered a new biomarker for GDM.

摘要

本研究目的是调查健康孕妇和妊娠期糖尿病（GDM）孕妇的胰腺衍生因子（PANDER）水平。本横断面研究共纳入50名连续诊断为GDM的患者和30名随机选择的年龄和孕龄匹配的健康孕妇。分析血清PANDER水平和其他变量。获得了当时的年龄、孕龄、血液样本, GDM组和对照组的血红蛋白A1c（HbA1c）水平相似。GDM组的体重指数（BMI）、空腹血糖、胰岛素、胰岛素抵抗的稳态模型评估（HOMA-IR）和血清PANDER水平显著高于对照组。最佳PANDER截断值为227.2ng/ml, 高于该值的比率灵敏度和特异性分别为100%和86.6％（p = .0001）。与对照组相比, GDM女性血清PANDER水平更高, 并且与胰岛素、HOMA-IR和HbA1c水平呈正相关。 这些结果表明PANDER可能被认为是GDM的新生物标志物。

The Chinese abstracts are translated by Prof. Dr. Xiangyan Ruan and her team: Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, China.

Keywords:

• Pancreatic-derived factor
• gestational diabetes mellitus
• FAM3B

Disclosure statement

The authors report no conflicts of interests.