Maternal serum levels of asymmetric dimethylarginine in normal and preeclamptic pregnancies

Abstract

The study aims to investigate maternal serum levels of asymmetric dimethylarginine (ADMA) in preeclampsia. Serum samples were collected from 57 women with preeclamptic pregnancies and 30 women with normal pregnancies during the third trimester. ADMA levels were measured with the ELISA method. ADMA levels in preeclamptic pregnancies were significantly higher when compared with normal pregnancies (2.35 ± 3.20 nmol/l versus 0.35 ± 0.10 nmol/l; p < .05). ADMA levels show a significant positive correlation with systolic and diastolic pressure, urea, and creatinine but a negative correlation with proteinuria. ADMA levels have a significant strong correlation with PE. ADMA levels are significantly higher in preeclamptic pregnancy compared with normal pregnancy.

摘要

本研究旨在探讨子痫前期（PE）孕妇血清不对称二甲基精氨酸（ADMA）水平, 从57例子痫前期妊娠晚期女性和30例正常妊娠晚期女性中采集血清样本, ELISA法测定ADMA水平。子痫前期孕妇血清ADMA水平明显高于正常孕妇（2.35±3.20nmol/l vs. 0.35±0.10nmol/l, P<0.05）, ADMA水平与收缩压、舒张压、尿素、肌酐呈显著正相关, 与蛋白尿呈负相关, ADMA水平与PE显著强相关, 子痫前期妊娠组ADMA水平明显高于正常妊娠组。

The Chinese abstracts are translated by Prof. Dr. Xiangyan Ruan and her team: Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, China.

Keywords:

• Asymmetric dimethylarginine (ADMA)
• preeclampsia
• pregnancy

Disclosure statement

The authors report no conflict of interest.