Outcomes of in vitro fertilization–embryo transfer in women with diminished ovarian reserve after growth hormone pretreatment

Abstract

The study was to evaluate the in vitro fertilization–embryo transfer (IVF-ET) outcomes in women with diminished ovarian reserve (DOR) after pretreatment with growth hormone (GH). Retrospective propensity score matching study, which included 92 women received GH over 4 weeks pretreatment before their subsequent IVF cycles and 92 matched controls who underwent IVF cycles between July 2017 and August 2018. The evaluation parameters included ovarian response, embryological parameters, and pregnancy outcomes after embryo transfer (ET). The mean number of retrieved oocytes and transferable day-3 embryos were significantly higher after GH pretreatment. The implantation rate, clinical pregnancy rate, and ongoing pregnancy rate per fresh ET cycle were similar between the GH group and control group. In women who either achieved pregnancy or utilized all the embryos resulting from the index stimulation cycle, the cumulative clinical pregnancy rate was significantly higher in women with GH compared to the control group. 4 weeks pretreatment with GH could increase ovarian response to stimulation and then improved IVF-ET outcomes in women with DOR.

摘要

本研究目的是评价卵巢储备功能减退（DOR）女性经生长激素（GH）预处理后的体外受精-胚胎移植（IVF-ET）结局。回顾性倾向评分匹配研究, 包括92名女性, 在随后的IVF周期前4周接受GH预处理, 以及匹配的92名对照组, 他们在2017年7月至2018年8月期间接受了IVF周期。评估参数包括卵巢反应、胚胎学参数和胚胎移植(ET)后的妊娠结局。GH预处理后平均获取卵母细胞数和可移植胚胎数均明显更高。GH组每新鲜胚胎移植周期的种植率、临床妊娠率和持续妊娠率与对照组相似。在妊娠或用所有刺激周期产生胚胎的女性中, GH组女性的累积临床妊娠率明显高于对照组。GH预处理4周可提高卵巢对刺激的反应性, 进而改善DOR患者的IVF-ET结局。

Keywords:

• Diminished ovarian reserve
• growth hormone
• in vitro fertilization
• fertilization embryos
• clinical outcomes

Acknowledgements

We thank the medical and administrative staff of the Reproductive Medical Center of Peking University Third Hospital for their assistance with maintaining the electronic database and assistance with data collection.

Ethics approval

Institutional review board approval for this study was obtained from the Ethics Committee of the Peking University Third Hospital (2018SZ-038). All patients provided generic consent for use of their personally unidentified data for research upon commencement of treatment.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

This study was supported by The Capital Health Research and Development of Special under Grant 2014-1-4091 and Key Clinical Program of Peking University Third Hospital under BYSY2015002.