Abstract
The aim of the study was to compare demographic, hormonal and clinical parameters in patients with premature ovarian insufficiency (POI) and women with early menopause in Greece. One hundred thirty-nine women of Greek origin, aged 14–45 years, referring for oligomenorrhea and having elevated FSH concentrations were divided into three groups regarding the age of menstrual disturbances onset [POI1: </=30 years (n = 42); POI2: 31–39 years (n = 36); early menopause: 40–45 years (n = 61)].
The mean age of menstrual disturbances onset and that of diagnosis in all POI and early menopause patients were 28.7 years (28.7 ± 7.7) versus 42.1 years (42.1 ± 1.5) and 33.8 years (33.8 ± 7.2) versus 43.3 years (43.3 ± 1.4), respectively. POI patients and women with early menopause were diagnosed, respectively, five years and approximately four to six months later than the age of menstrual disturbances onset. Moreover, FSH2 (second confirmatory FSH measurement at 4-to-6-weeks interval) was greater in all POI patients than in early menopause women (55.4 ± 33.9 vs. 32.4 ± 19.4; p < .05) whereas mean age of menarche was greater in early menopause women than in POI patients (13 ± 1.3 vs. 12 ± 2.2; p < .05). Furthermore, FSH2 was increased in all POI and decreased in early menopause patients.
摘要
这项研究的目的是比较希腊早发性卵巢功能不全 (POI) 患者和早绝经妇女的人口统计学、激素和临床参数。139名年龄在14-45岁之间, 涉及月经过少和FSH浓度升高的希腊裔女性, 根据月经紊乱的开始年龄分为三组[POI1: <=30岁 (n=42); POI2: 31-39岁 (n=36); 早绝经: 40-45岁 (n=61)]。
所有POI和早绝经患者月经紊乱开始和诊断的平均年龄分别为28.7 (28.7±7.7) 岁和42.1 (42.1±1.5) 岁, 33.8 (33.8±7.2) 岁和43.3 (43.3±1.4) 岁。POI患者和早绝经妇女被诊断的年龄分别比月经紊乱开始年龄晚5年和大约4到6个月。此外, 所有POI患者的FSH2 (间隔4-6周的第二次确认性FSH测定)均高于早绝经妇女 (55.4±33.9 vs. 32.4±19.4; p<0.05);而早绝经妇女的月经初潮平均年龄大于POI患者 (13±1.3 vs. 12±2.2; p<0.05)。此外, 所有POI患者的FSH2升高, 早绝经患者降低。
The Chinese abstracts are translated by Prof. Dr. Xiangyan Ruan and her team: Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, China.
Compliance with Ethical Standards
All procedures performed in the study were in accordance with the ethical standards of the institutional and national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
Informed consent
Informed consent was obtained from all individual participants included in the study.
Author contributions
All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.
Disclosure statement
No potential conflict of interest was reported by the author(s).