Association of renalase gene polymorphisms with the risk of hypertensive disorders of pregnancy in northeastern Han Chinese population

Abstract

Renalase is a novel enzyme that can regulate blood pressure by degrading circulating catecholamines. We aimed to evaluate the possible effect of rs2296545, rs2576178 and rs10887800 polymorphisms of the renalase gene (RNLS) on the development of hypertensive disorders of pregnancy (HDP). This case-control study consisted of 185 patients with HDP and 380 normotensive pregnant women from the northeastern Chinese Han population. Association analyses were performed using PLINK, to compare allele and genotype frequencies in cases and controls. Adjustment for logistic regression analysis was performed by permutation testing. In the HDP patients compared with controls, we found that there was statistically significant difference in genotype distribution of rs2296545 (p = .037). Rs2296545 and rs2576178 polymorphisms have 1.91-fold (p = .004) and 1.73-fold (p = .015) increased risk of HDP in the dominant model, respectively. When compared preeclampsia (PE) to control, the RNLS rs2296545 polymorphism was significantly associated with PE risk in the dominant model (p = .021). We next analyzed the haplotypes of these SNPs and there was no difference between controls and HDP or PE. These findings suggest that rs2296545 was significantly associated with HDP and PE risk and the rs2576178 polymorphism may increase the susceptibility to HDP.

摘要

肾酶是一种通过降解循环儿茶酚胺来调节血压的新型酶。我们的目的是评估肾酶基因（RNLS）的rs2296545, rs2576178 和 rs10887800多态性对妊娠期高血压病（HDP）发展的可能影响。本病例对照研究由185例HDP患者和380例正常妊娠的中国东北汉族人群组成。采用PLINK进行关联分析, 比较病例和对照组的等位基因和基因型频率。Logistic回归分析采用置换检验进行调整。在HDP患者中, 我们发现rs2296545基因型分布与对照组比较差异有统计学意义（p=0.037)。 Rs2296545 和 rs2576178多态性在优势模型中患HDP风险分别增加1.91倍（p=.004）和1.73倍（p=.015)。将子痫前期（PE）与对照组相比, 优势模型中RNLS rs2296545多态性与PE风险显著相关（p=.021）。接下来, 我们分析了这些SNPs的单倍型, 发现对照组与HDP或PE之间没有差异。这些结果提示rs2296545与HDP和PE的风险显著相关, 而rs2576178多态性可能增加HDP的易感性。

Keywords:

• Hypertensive disorders of pregnancy
• renalase
• SNP
• preeclampsia

Disclosure statement

The authors declare that they have no conflicts of interest.

Additional information

Funding

This study was supported by the National Natural Science Foundation of China (No. 81671689).