Association of decreased myonectin levels with metabolic and hormonal disturbance in polycystic ovary syndrome

Abstract

Myonectin is a myokine involving in glucose and lipid metabolisms. Polycystic ovary syndrome (PCOS) is a metabolic and reproductive disorder associated with insulin resistance. Our aims were to discover whether myonectin levels were altered in PCOS women comparing to controls and to determine the link of myonectin with hormonal-metabolic parameters in PCOS women. The current research was designed as a case-control study. Seventy-two subjects with PCOS and 72 age- and body mass index (BMI)-matched subjects as controls were enrolled into the study. Circulating myonectin levels were measured by ELISA. Myonectin levels were significantly lower in PCOS subjects compared to controls (6.77 ± 1.96 vs. 9.14 ± 2.87 ng/ml, p< .001). Myonectin exhibited an inverse association with BMI, insulin resistance, free androgen index (FAI) and triglycerides whereas it showed a positive association with high-density lipoprotein cholesterol (HDL-C) in women with PCOS. Logistic regression analysis revealed that decreased myonectin levels were parallel with increased probability of having PCOS risk. Decreased myonectin levels were associated with metabolic and hormonal disturbances in PCOS women, suggesting that myonectin may play a role in pathophysiology of PCOS.

摘要

肌连素是一种与糖脂代谢相关的肌肉因子。多囊卵巢综合征（PCOS）是一种与胰岛素抵抗相关的生殖代谢疾病。我们的研究目的是想通过与对照组相比, 观察PCOS患者的肌连素水平是否发生改变, 并探索PCOS患者肌连素与内分泌代谢指标间的关系。本研究为病例对照研究。本研究纳入72名PCOS患者作为病例组, 并根据年龄和体质量指数（BMI）匹配72名对照组患者。采用ELISA法测定血中肌连素的水平。与对照组相比, PCOS患者的肌连素水平明显降低（6.77 ± 1.96 vs. 9.14 ± 2.87 ng/ml, p< .001）。PCOS患者肌连素与BMI、胰岛素抵抗、游离雄激素指数（FAI）和甘油三酯呈负相关, 而与高密度脂蛋白胆固醇（HDL-C）呈正相关。Logistic回归分析结果显示, 肌连素水平降低的同时PCOS的风险相应增加。肌连素水平下降与PCOS女性内分泌代谢紊乱相关, 这有可能提示肌连素在PCOS的病理生理过程中发挥作用。

Keywords:

• Polycystic ovary syndrome
• myonectin
• insulin resistance
• body mass index
• hyperandrogenism

Author contributions

I.D. and A.G. participated in study design, provided serum samples, performed ELISA, analyzed and contributed to discussions of data interpretation, wrote, reviewed and edited the manuscript. I.D. is the guarantor of this work and, as such, had full access to all the data in the study and took responsibility for the integrity of the data and the accuracy of the data analysis.

Compliance with ethical standards: The subjects gave their oral and written informed consent before their inclusion in the study. The study adhered strictly to the principles of the Declaration of Helsinki as revised in 2008.

Disclosure statement

No potential conflict of interest was reported by the author(s).