The role of serum osteoprotegerin level in diagnosis of disease and determining cardiovascular risk of polycystic ovary syndrome

Abstract

Objective: Although animal studies claim that osteoprotegerin (OPG) is preventive on this system, there are conflicting results in human studies. The aim of this study was to investigate the role of OPG in the diagnosis and determination of cardivovascular risk in patients with polycystic ovary syndrome (PCOS), which is a multisystem effective disease.

Method: The study was performed on 28 premenopausal healthy female volunteers and 57 newly diagnosed PCOS patients in 2017. Anamnesis was obtained, body mass indexes were calculated, laboratory tests required for diagnosis and differential diagnosis of PCOS and suprapubic ovarian ultrasonography were performed, serum OPG level was studied by enzyme-linked immunosorbent assay.

Results: OPG levels were similar in PCOS and control groups and there was no significant difference (49.392 ± 10.973 pg/ml vs 49.567 ± 13.57 pg/ml, p = .815). Correlation analysis showed a positive correlation between OPG and total testosterone levels in the PCOS group (r = 0.277, p = .045). No significant relationship with cardiovascular and metabolic parameters was detected.

Conclusion: No difference was found between PCOS patients and control groups in terms of OPG levels. Therefore, it is thought that OPG level cannot be used in the diagnosis of the disease. There was no significant relationship between cardiometabolic parameters.

摘要

目的：虽然动物实验证实护骨素(OPG)对这一系统有预防作用, 但在人类研究中却有相互矛盾的结果。本研究旨在探讨护骨素(OPG)在多囊卵巢综合征(PCOS)疾病的诊断和心血管病风险判断中的作用。

方法：本研究包括28名绝经前健康女性志愿者和57例新诊断的多囊卵巢综合征患者, 研究时间为2017年。记录她们的病史, 计算体重指数, 进行多囊卵巢综合征(PCOS)诊断和鉴别诊断所需的实验室检查和卵巢超声检查, 用酶联免疫吸附法测定血清OPG水平。

结果：多囊卵巢综合征组与对照组骨钙素水平相近, 无明显差异 (49.392±10.973pg/ml vs 49.567±13.57pg/ml, p=.815)。相关分析显示, 多囊卵巢综合征组骨钙素水平与总睾酮水平呈正相关(r=0.277, p=.045)。与心血管和代谢参数无关。

结论：PCOS组与对照组OPG水平无明显差异。因此, 认为OPG水平不能用于该疾病的诊断。心脏代谢参数之间无明显相关性。

Keywords:

• Osteoprotegerin
• polycystic ovary syndrome
• cardiovascular
• metabolic
• insulin resistance

Limitations

The main limitation is the smallness of the sample size. The numerical variables did not show normal distribution, so this limits the contribution of the study to the literature. The other limitation was that the two groups were not similar in age, but age did not correlate with both OPG and other parameters.

Ethical approval

The local ethics committee approved this study. All procedures were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

It was obtained from all participants.

Disclosure statement

All authors declare that they have no conflict of interest.