Abstract
This study aimed to study the dynamic thiol/disulfide homeostasis in pregnant women with gestational diabetes mellitus (GDM). Forty-five pregnant women with GDM and 45 age-matched healthy pregnancies were included in this study. Thiol/disulfide homeostasis was measured using a commercial kit (Rel Assay Diagnostics). The patients with GDM had significantly higher disulfide concentrations than healthy pregnant patients (p = .001). Besides, the GDM group had significantly higher disulfide/total thiol, disüplhide/native thiol, and native thiol/total thiol ratio than healthy pregnant patients (p = .001, p = .001 and p = .001, respectively). The significantly higher concentrations of disulfide, disulfide/total thiol, disüplhide/native thiol, and native thiol/total thiol ratio in women with GDM could be considered as the increased oxidative stress.
摘要
本研究旨在研究妊娠期糖尿病(GDM)孕妇体内巯基/二硫代谢物的动态稳态。45名妊娠期糖尿病孕妇和45名年龄匹配的健康孕妇参加了这项研究。使用商业试剂盒(REL化验诊断)测量硫醇/二硫化物动态平衡。妊娠期糖尿病患者的二硫化物浓度显著高于健康孕妇(p=.001)。此外, 妊娠期糖尿病组二硫/总硫醇、二硫/天然硫醇、天然硫醇/总硫醇比值均显著高于健康孕妇(分别为P=.001、P=.001和P=.001)。妊娠期糖尿病患者体内二硫化物、二硫化物/总硫醇、二硫化氢/天然硫醇、天然硫醇/总硫醇比值明显升高, 可认为是氧化应激增加。
Disclosure statement
No potential conflict of interest was reported by the author(s).