Frozen blastocyst transfer improves the chance of live birth in women with endometrioma

Abstract

Purpose: The existing literature is scarce regarding outcomes of fresh vs frozen embryo blastocyst transfers in women with endometrioma. The goal of the study was to compare outcomes between fresh and frozen blastocyst transfers (fresh-BT vs. frozen-BT) in endometrioma-affected women.

Materials and methods: This study included 315 endometrioma-affected women aged between 20 and 39 years who underwent blastocyst transfer. Primary outcome was live birth rate (an alive birth after 24 completed weeks gestation).

Results: The study groups did not differ in terms of patient characteristics and treatment variables. The live birth rate was 40.7% in fresh-BT group and 56.1% in frozen-BT group (OR:1.86, 95% CI:1.18–2.92 p = .007). The approach of frozen embryo transfer was an independent factor of live birth (adjusted OR:1.83, 95% CI:1.16–2.90, p = .009).

Conclusion: The approach of frozen blastocyst transfer increases the chance of live birth in endometrioma-affected patients compared with fresh blastocyst transfer. Thus, a frozen embryo transfer may be the choice of strategy in these patients.

Chinese abstract

目的：目前关于子宫内膜异位囊肿患者新鲜囊胚移植与冷冻囊胚移植比较的文献较少。本研究目的是就子宫内膜异位囊肿性不孕的女性接受新鲜囊胚移植与和冷冻囊胚移植进行临床结局的比较。材料和方法：本研究纳入了315名年龄在20 - 39岁的子宫内膜异位囊肿不孕患者, 他们都接受了囊胚移植。主要结局为活产率（妊娠24周后的活产）。结果：两组患者的基本特征和治疗方式无明显差异。新鲜囊胚移植组的活产率为40.7%, 冷冻囊胚移植组的活产率为56.1% （OR:1.86, 95% CI:1.18-2.92 p=.007）。冷冻囊胚移植是影响活产率的独立影响因素（调整后OR:1.83, 95% CI:1.16-2.90, p=.009）。结论：与新鲜囊胚移植相比, 冷冻囊胚移植提高了子宫内膜异位囊肿患者的活产率。因此, 冷冻囊胚移植可作为是这类患者辅助生殖的一种选择。

Keywords:

• Endometrioma
• infertility
• fresh transfer
• frozen transfer
• live birth

Disclosure statement

The authors declare that they have no conflict of interest.