Abstract
Purpose: The present study aimed to examine the association between the stage of pelvic organ prolapse (POP) and the risk of fracture in postmenopausal women.
Methods: A cross-sectional design was used, which included 133 women with POP over 50 years of age. The participants were classified according to their POP stage, underwent blood tests (hemogram, biochemistry, bone remodeling markers, and hormone tests), and completed a sociodemographic and lifestyle questionnaire along with densitometry, FRAX, and FRIDEX tests.
Results: Of the 133 women studied, 66 presented stages I-II POP (49.6%) and 67 III-IV POP (50.4%). The mean age of the participants was 64.47 years. Women with a high POP stage showed higher FRAX scores for major osteoporotic and hip fracture (p .001 and p < .001p). Bivariate analysis revealed that higher scores on the FRIDEX scale were associated with a higher POP stage (p = .032). In addition, there was a marginally significant negative association between bone mineral density (BMD) and POP stage (p = .054).
Conclusions: High-stage POP can be considered an independent predictor of osteoporotic fracture risk, as measured using the FRAX and FRIDEX scales.
摘要
目的
本研究旨在探讨绝经后妇女盆腔器官脱垂(POP)分期与骨折风险之间的关系。
方法
采用横断面设计, 包括133名50岁以上的POP患者。参与者根据其POP阶段进行分类, 接受血液测试(血象、生化、骨重塑标志物和激素测试), 并完成社会人口统计学和生活方式问卷以及密度测定、FRAX和FRIDEX测试。
结果
在所研究的133名女性中, 66名女性出现了I-II期POP(49.6%)和67名III-IV期POP(50.4%), 参与者的平均年龄为64.47岁。具有高POP阶段的女性在严重骨质疏松和髋部骨折方面表现出较高的FRAX评分(p.001和p<0.001p)。双变量分析表明, FRIDEX评分较高与较高的POP阶段相关(p=.032)。此外, 骨密度(BMD)与POP阶段之间存在轻微的负相关(p=.054)。
结论
使用FRAX和FRIDEX量表测量, 高阶段POP可被视为骨质疏松性骨折风险的独立预测因子。
Acknowledgements
This manuscript has been translated and edited by Your English Lab.
Disclosure statement
The authors declare no conflict of interest, while no funding has been received for the execution of this study.
Ethical approval
This study was approved by the Research Ethics Committee of the Province of Jaén (before its initiation) with a favorable report and signed informed consent obtained from the patients (Annex 1).
Funding
The author(s) reported there is no funding associated with the work featured in this article.