Implementation of pharmacogenomics testing for precision medicine

Abstract

Great strides have been made in the past decade to lower barriers to clinical pharmacogenomics implementation. Nevertheless, PGx consultation prior to prescribing therapeutics is not yet mainstream. This review addresses the current climate surrounding PGx implementation, focusing primarily on strategies for implementation at academic institutions, particularly at The University of Chicago, and provides an up-to-date guide of resources supporting the development of PGx programs. Remaining challenges and recent strategies for overcoming these challenges to implementation are discussed.

Keywords:

• Pharmacogenomics
• implementation
• precision medicine
• clinical guideline

Acknowledgments

The CPTC at The University of Chicago is a multidisciplinary team that relies on the collaboration of key faculty and staff, including: Dr. Mark Ratain, Dr. Randall Knoebel, Dr. Seth Hartman, Dr. Anish Choksi, David George, Larry House, and Matthew Jack.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

The authors have no relevant financial support to disclose concerning the subject matter or materials discussed in this article.