Synthesis, synthetic interests, and biological activities of β-substituted vinylphosphonates

Abstract

β-Substituted vinylphosphonates constitute an original class of organophosphorus reagents of which several compounds exhibit attractive biological properties. The review exemplifies and discusses the different synthetic methods described for their synthesis, which involve well known reactions, but also more specifically designed methods. In addition, the uses as synthetic intermediates as well as the therapeutic uses of the title compounds are also summarized.

Graphical abstract

Keywords:

• Functionalized vinylphosphonates
• β-substituted vinylphosphonates
• biologically active phosphonates
• aminovinylphosphonates

Disclosure statement

No potential conflict of interest was reported by the author(s).

Notes

1 Chorismic acid is the starting point for the biosynthesis of aromatic aminoacids via enzymatic catalysis by chorismate mutase. Therefore, inhibition of this enzyme is of interest for the design of new antibacterial agents.