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Leukemia & Lymphoma Volume 61, 2020 - Issue 9
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Letters to the Editor

Progressive multifocal leukoencephalopathy during treatment with lenalidomide and elotuzumab for multiple myeloma

Yuta UsuiDepartment of Neurology and Neurobiology of Aging, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan; View further author information
,
Hiroto NakanoDepartment of Neurology and Neurobiology of Aging, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan; View further author information
,
Junji KomatsuDepartment of Neurology and Neurobiology of Aging, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan; View further author information
,
Kazuo NakamichiDepartment of Virology 1, National Institute of Infectious Diseases, Tokyo, Japan; View further author information
,
Masayuki SaijoDepartment of Virology 1, National Institute of Infectious Diseases, Tokyo, Japan; View further author information
,
Seiichiro TakanoDepartment of Neurology, Fukui Red Cross Hospital, Fukui, Japan; View further author information
,
Ken-ichi KamiyaDepartment of Hematology, Fukui Red Cross Hospital, Fukui, JapanView further author information
,
Tsuyoshi HamaguchiDepartment of Neurology and Neurobiology of Aging, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan; View further author information
&
Masahito YamadaDepartment of Neurology and Neurobiology of Aging, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan; Correspondence[email protected]
View further author information
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Pages 2234-2237 | Received 11 Mar 2020, Accepted 27 Apr 2020, Published online: 18 May 2020
 
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Ethics approval

This is not a clinical trial, but a case report. Although the patient was treated with mefloquine and mirtazapine, which are not approved as medications for PML by pharmaceutical and medical device agencies in Japan, the institutional committee for the evaluation of highly difficult new medical technologies approved the treatment.

Author contributions

YU, HN, JK, ST, KK, TH, and MY performed the clinical and bedside studies. KN, MS and ST performed the PCR for the detection of JCV. YU wrote the initial draft of the paper and all authors contributed to its preparation. The final version was read and approved by all authors.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

This work was supported by JSPS KAKENHI [Grant Number 17H04194] (to KN).

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