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Leukemia & Lymphoma Volume 64, 2023 - Issue 11
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Original Articles

The altered metabolic pathways of diffuse large B-cell lymphoma not otherwise specified

Carla Isabelly Rodrigues-Fernandesa Department of Oral Diagnosis, Semiology and Pathology Areas, Piracicaba Dental School, University of Campinas (UNICAMP), Piracicaba, São Paulo, BrazilORCID Iconhttps://orcid.org/0000-0002-1290-6235View further author information
ORCID Icon,
Roberta Rayra Martins-Chavesb Department of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, BrazilView further author information
,
Jéssica Gardone Vitóriob Department of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, BrazilView further author information
,
Filipe Fideles Duarte-Andradeb Department of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, BrazilView further author information
,
Thaís dos Santos Fontes Pereirab Department of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, BrazilView further author information
,
Ciro Dantas Soaresc Getúlio Sales Laboratory, Rio Grande do Norte, Natal, BrazilView further author information
,
Victor Rezende Moreirad Department of Sanitation and Environmental Engineering, School of Engineering, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, BrazilView further author information
,
Yuri Abner Rocha Lebrond Department of Sanitation and Environmental Engineering, School of Engineering, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, BrazilView further author information
,
Lucilaine Valéria de Souza Santosd Department of Sanitation and Environmental Engineering, School of Engineering, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, BrazilView further author information
,
Liséte Celina Langed Department of Sanitation and Environmental Engineering, School of Engineering, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, BrazilView further author information
,
Gisele André Baptista Canutoe Department of Analytical Chemistry, Institute of Chemistry, Universidade Federal da Bahia (UFBA), Salvador, BrazilView further author information
,
Carolina Cavaliéri Gomesf Department of Pathology, Biological Sciences Institute, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, BrazilView further author information
,
Adriana Nori de Macedog Department of Chemistry, Exact Sciences Institute, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, BrazilView further author information
,
Hélder Antônio Rebelo Pontesh Service of Oral Pathology, João de Barros Barreto University Hospital, Federal University of Pará (UFPA), Belém, BrazilView further author information
,
Rommel Mario Rodríguez Burbanoh Service of Oral Pathology, João de Barros Barreto University Hospital, Federal University of Pará (UFPA), Belém, BrazilView further author information
,
Manoela Domingues Martinsi Department of Pathology, School of Dentistry, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, BrazilView further author information
,
Fábio Ramôa Piresj Oral Pathology, Dental School, Rio de Janeiro State University (UERJ), Rio de Janeiro, BrazilView further author information
,
Ricardo Alves Mesquitab Department of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, BrazilView further author information
,
Ricardo Santiago Gomezb Department of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, BrazilView further author information
,
Alan Roger Santos-Silvaa Department of Oral Diagnosis, Semiology and Pathology Areas, Piracicaba Dental School, University of Campinas (UNICAMP), Piracicaba, São Paulo, BrazilView further author information
,
Márcio Ajudarte Lopesa Department of Oral Diagnosis, Semiology and Pathology Areas, Piracicaba Dental School, University of Campinas (UNICAMP), Piracicaba, São Paulo, BrazilView further author information
,
Pablo Agustin Vargasa Department of Oral Diagnosis, Semiology and Pathology Areas, Piracicaba Dental School, University of Campinas (UNICAMP), Piracicaba, São Paulo, BrazilView further author information
&
Felipe Paiva Fonsecab Department of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, BrazilCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-6657-4547View further author information
ORCID Icon show all
Pages 1771-1781 | Received 13 Jan 2023, Accepted 27 Jun 2023, Published online: 18 Jul 2023
 
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Abstract

Altered metabolic fingerprints of Diffuse large B-cell lymphoma, not otherwise specified (DLBCL NOS) may offer novel opportunities to identify new biomarkers and improve the understanding of its pathogenesis. This study aimed to investigate the modified metabolic pathways in extranodal, germinal center B-cell (GCB) and non-GCB DLBCL NOS from the head and neck. Formalin-fixed paraffin-embedded (FFPE) tissues from eleven DLBCL NOS classified according to Hans’ algorithm using immunohistochemistry, and five normal lymphoid tissues (LT) were analyzed by high-performance liquid chromatography-mass spectrometry-based untargeted metabolomics. Partial Least Squares Discriminant Analysis showed that GCB and non-GCB DLBCL NOS have a distinct metabolomics profile, being the former more similar to normal lymphoid tissues. Metabolite pathway enrichment analysis indicated the following altered pathways: arachidonic acid, tyrosine, xenobiotics, vitamin E metabolism, and vitamin A. Our findings support that GCB and non-GCB DLBCL NOS has a distinct metabolomic profile, in which GCB possibly shares more metabolic similarities with LT than non-GCB DLBCL NOS.

Disclosure statement

The authors declare that they have no conflict of interest.

Additional information

Funding

This study was supported by the Coordination for the Improvement of Higher Education Personnel (CAPES), the National Council for Scientific and Technological Development (CNPq), the São Paulo State Research Foundation (FAPESP), and the Minas Gerais State Research Foundation (FAPEMIG).

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