Response and local control in patients treated with low-dose radiotherapy for tumoral mycosis fungoides

Abstract

Low-dose radiotherapy (LDRT), defined in this study as 2 fractions of 4 Gy delivered on consecutive days, is an effective option for local palliation of mycosis fungoides (MF), but its efficacy for tumoral lesions (TL) needs investigation. We assessed response and local control (LC) rates for patients treated with LDRT for MF and compared these outcomes between TL and non-TL. A total of 73 lesions in 18 patients treated with LDRT between 2013-2020 were analyzed. Response was defined as complete response (CR), partial response (PR), or no response (NR). In the non-TL versus TL groups, CR was observed in 16.7% v. 4.0%, PR in 81.2% v. 80.0%, NR in 2.1% v. 16.0%, respectively. 2-year LC was 100% for non-TL and 61% for TLs (p < 0.01). LDRT yields excellent response and lesion control for non-TLs and is associated with lower response rates and LC for TLs.

KEY MESSAGE

Low-dose radiation therapy yields excellent response and lesion control for non-tumoral lesions.

Keywords:

• Cutaneous t-cell lymphoma
• dermatopathology
• oncology
• radiation therapy
• tumor

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

We would like to acknowledge the data management services of the Wake Forest Clinical and Translational Science Institute (WF CTSI), which is supported by the National Center for Advancing Translational Sciences (NCATS), National Institutes of Health, through Grant Award Number UL1TR001420. Dr. Lindsay Strowd has received consulting fees from Sanofi, Galderma, Lilly Personal, and Incyte.