The value of adiponectin-resistin (AR) index in newly diagnosed obesity hypertension: a case control study among Chinese adult

ABSTRACT

Objective

To explore the role of adiponectin-resistin (AR) index as a better indicator of obesity-related hypertension.

Method(s)

This study continued a case control study that had finished recruiting 153 subjects divided as four characteristic groups. Fasting serum resistin levels (FSR) and Fasting serum adiponectin levels (FSA) were tested by ELISA. And, other related anthropometric clinical and metabolic data were collected. Analyzation on correlations between research index and differences between groups were done by SPSS. AR index’s performance was also validated by the receiver operating characteristic (ROC) curves, the net reclassification improvement (NRI), and the integrated discrimination improvement (IDI).

Result(s)

The AR index was defined as 1+ log₁₀(R₀)-log₁₀(A₀). AUC of the AR index was 0.660 and NRI and IDI indicated AR index outperformed FSA alone. AR index statistically significantly negatively correlated with SB and DB and positively with ALB and SCR. AR index was statistically significantly different between the NH group and OH group and more specific than FSR alone as a biomarker of obesity-related hypertension.

Conclusion(s)

The AR index was more strongly associated with increased risk of obesity-related hypertension than the solely index of FSR or FSA and was useful for early diagnosis of obesity-related hypertension.

KEYWORDS:

• Adiponectin-resistin index (AR index)
• obesity
• hypertension
• blood pressure
• validity

Disclosure statement

The authors declare no conflict of interest.

Additional information

Funding

This work was supported by grants from the National Natural Science Foundation of China (81102200/H2610).