ABSTRACT
Objectives
This study explored the miR-101 clinical significance in hypertensive disorder complicating pregnancy (HDCP).
Methods
Pregnant women with gestational hypertension (GH)/mild preeclampsia (mPE)/severe preeclampsia (sPE) were included. The miR-101 levels were measured. Correlation between miR-101 and soluble fmslike tyrosine kinase-1 (sFlt-1), miR-101 predictive value, and factors influencing HDCP grade were evaluated.
Results
Serum miR-101 was down-regulated and negatively correlated with sFlt-1. miR-101 was an independent risk factor for HDCP and decreased with HDCP severity. The area under the curve of miR-101 in differentiating GH from mPE and mPE from sPE was 0.7764 and 0.8529.
Conclusion
Serum miR-101 level may be a biomarker for grading HDCP.
Disclosure statement
No potential conflict of interest was reported by the author(s).
Ethics approval
This study was approved by Academic Ethics Committee of Jincheng People’s Hospital (Approval number: JCP.No20200120001). All study subjects were informed of the study purpose and signed informed consent. All methods were carried out in accordance with relevant guidelines and regulations.
Availability of data and materials
All the data generated or analyzed during this study are included in this published article.
Authors’ contributions
YL contributed to the study concepts and study design, YW contributed to the guarantor of integrity of the entire study; YW contributed to the literature research; YL contributed to the experimental studies and data acquisition; YL, YW contributed to the manuscript preparation and JS contributed to the manuscript editing and review. All authors read and approved the final manuscript.