Potential biomarkers in endometrial cancer: a narrative review

Abstract

Context

Every year, approximately 0.4 million women suffer from endometrial cancer (EC) worldwide and it has become the most common gynecological malignancy. Almost 66% of EC cases are diagnosed at an early stage and can be cured by performing surgery while those at an advanced stage turns out to be fatal. Biomarkers of endometrial cancer would be very valuable for screening of women who are at high risk and in detecting the chance of recurrence of disease.

Objective

The current article has reviewed studies published on expression of biomarkers and susceptibility to EC.

Methods

Google Scholar and PubMed were used as searching platforms and we have majorly considered the literature from last 10 years.

Results

Potential biomarkers of EC identified from various studies were summarised.

Graphical Abstract

Keywords:

• Endometrial cancer
• biomarker
• mutation
• classification
• angiogenic factors

Acknowledgement

Kareena Moar is a recipient of fellowship from Haryana State Council for Science, Innovation and Technology (HSCSIT-3946). This agency had no role in the interpretation or writing the manuscript. Anuja Pant is a recipient of junior research fellowship from The Indian Council of Medical Research (ICMR), Government of India (5/10/FR/03/2021-RBMCH).

Author contributions

Kareena moar: Conceptualisation, Writing - Original draft preparation. Anuja Pant: Writing and Editing. Vikas Saini: Supervision, Reviewing and Editing. Pawan Kumar Maurya: Supervision, Reviewing and Editing.

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

The Indian Council of Medical Research (ICMR), Government of India, is gratefully acknowledged by Pawan Kumar Maurya for giving financial assistance (5/10/FR/03/2021-RBMCH).