The association between vitamin D receptor FokI gene polymorphism and osteoporosis in postmenopausal women: a meta-analysis

Abstract

Objective

This study aimed to quantitatively summarize the evidence for vitamin D receptor (VDR) FokI gene polymorphism and osteoporosis risk in Caucasian and Asian postmenopausal women.

Materials and methods

The PubMed, EMBASE, Weipu, CNKI, and Wanfang databases were searched for eligible studies. Case–control studies containing available genotype frequencies for F/f were chosen, and the odds ratio (OR) with 95% confidence interval (CI) was used to assess the strength of this association.

Results

In total, 3349 osteoporosis cases and 3202 controls were identified in our meta-analysis. In the stratified analysis, a significant association was observed between VDR FokI gene polymorphism and postmenopausal osteoporosis susceptibility in Asian subjects (additive model: OR = 1.529, 95% CI 1.053–2.219, p = 0.026; dominant model: OR 2.711, 95% CI 1.693–4.342 p < 0.001; co-dominant model: ff vs. FF, OR 2.796, 95% CI 1.439–5.433 p = 0.002), and we failed to find any significant relationship in Caucasian populations.

Conclusion

The present meta-analysis suggests that the VDR FokI genotype is associated with increased risk of osteoporosis in Asian women but not in Caucasian women. To draw comprehensive and true conclusions, further prospective studies with larger numbers of participants worldwide are needed to examine associations between VDR FokI polymorphism and osteoporosis.

摘要

目的：本研究旨在定量总结高加索和亚洲绝经后女性维生素D受体（VDR）FokI基因多态性与骨质疏松风险的证据。

材料与方法：检索PubMed、EMBASE、Weipu、CNKI和万方数据库, 查找符合条件的研究。选择了包含F/f基因型频率的病例对照研究, 用95%可信区间（CI）的优势比（OR）来评估这种关联的强度。

结果：在我们的meta分析中, 共鉴定出3349例骨质疏松症病例和3202例对照。在分层分析中, 亚洲人群中VDR FokI基因多态性与绝经后骨质疏松症的易感性显著相关（加法模型：OR=1.529, 95%CI 1.053∼2.219, p=0.026；显性模型：OR 2.711, 95%CI 1.693-4.342 p<0.001；共显性模型：ff vs FF, OR 2.796, 95%CI 1.439-5.433 p=0.002）, 在高加索人群中未发现明显的相关性。

结论：目前的meta分析表明, VDR FokI基因型与亚洲女性骨质疏松风险的增加有关, 但与高加索女性的骨质疏松症风险增加无关。为了得出全面和真实的结论, 需要在全球范围内对更多的参与者进行进一步的前瞻性研究, 以检查VDR FokI基因多态性与骨质疏松症之间的关系。

Keywords:

• Vitamin D receptor
• FokI polymorphism
• osteoporosis
• postmenopausal
• meta-analysis

Potential conflict of interest

No potential conflict of interest was reported by the author(s).

Source of funding

Nil.