Abstract
Objective
This article reports the first case of pregnancy after frozen–thawed ovarian tissue transplantation to prevent iatrogenic premature ovarian insufficiency in China.
Methods
Ovarian tissue cryopreservation was performed in a patient with myelodysplastic syndrome (MDS) before multi-agent chemotherapy and hematopoietic stem cell transplantation. Two years later, she showed complete remission from MDS, and six frozen–thawed ovarian tissue strips were transplanted into the peritoneal pocket.
Results
The patient’s ovarian activity was restored 3 months after transplantation, and pregnancy occurred spontaneously 27 months after grafting. Until now, the pregnancy has progressed for 30 weeks, and the repeated ultrasound showed normal fetal development.
Conclusion
This is the first pregnancy resulting from ovarian tissue cryopreservation and transplantation in China.
中国冻存卵巢组织移植预防医源性早发性卵巢功能不全首例妊娠 摘要
目的:这篇文章报道中国冻存卵巢组织移植预防医源性早发性卵巢功能不全后首例妊娠。
方法:对1例骨髓增生异常综合征(MDS)患者, 在造血干细胞移植前的多药化疗前行卵巢组织冷冻保存。两年后, 她的 MDS 完全缓解, 将六片冻存的卵巢组织移植到腹膜袋中。
结果:患者移植后3个月卵巢功能恢复, 移植后27个月自然妊娠。目前, 妊娠进展到30周, 复查B超显示胎儿发育正常。
结论:这是中国卵巢组织冻存移植后首例妊娠。
Potential conflict of interest
No potential conflict of interest was reported by the authors.