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Modern Rheumatology Volume 29, 2019 - Issue 1
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Case Report

Intravascular large B-cell lymphoma with a high titer of proteinase-3-anti-neutrophil cytoplasmic antibody mimicking granulomatosis with polyangiitis

Yutaka ShinkawaDepartment of Clinical Immunology and Rheumatology, the Tazuke-Kofukai Medical Research Institute, Kitano Hospital, Osaka, JapanCorrespondence[email protected]
,
Saori HatachiDepartment of Clinical Immunology and Rheumatology, the Tazuke-Kofukai Medical Research Institute, Kitano Hospital, Osaka, Japan
&
Masato YagitaDepartment of Clinical Immunology and Rheumatology, the Tazuke-Kofukai Medical Research Institute, Kitano Hospital, Osaka, Japan
Pages 195-197 | Received 04 Feb 2016, Accepted 31 May 2016, Published online: 11 Jul 2016
 
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Abstract

A 63-year-old man presented with fever, sinusitis, otitis, and high titers of proteinase-3 anti-neutrophil cytoplasmic antibody (PR3-ANCA). Granulomatosis with polyangiitis (GPA) was first suspected. However, nasal mucosa and skin biopsies revealed the presence of intravascular large B-cell lymphoma (IVLBCL). We present a rare case of IVLBCL with a high titer of PR3-ANCA mimicking GPA.

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