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Modern Rheumatology Volume 29, 2019 - Issue 1
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Case Report

Manifestations of systemic lupus erythematosus in female patients with polysomy X: Possible roles of chromosome X

Taro IwamotoDepartment of Allergy and Clinical Immunology, Chiba University Hospital, Chiba, Japan, ;Department of Immunology, Division of Rheumatology, Mayo Clinic, Rochester, MN, USA, and
,
Masanori FujimotoDepartment of Allergy and Clinical Immunology, Chiba University Hospital, Chiba, Japan, ;Department of Diabetes, Metabolism and Endocrinology, Chiba University Hospital, Chiba, Japan
,
Kei IkedaDepartment of Allergy and Clinical Immunology, Chiba University Hospital, Chiba, Japan, Correspondence[email protected]
,
Aiko SakuDepartment of Allergy and Clinical Immunology, Chiba University Hospital, Chiba, Japan,
,
Sohei MakitaDepartment of Allergy and Clinical Immunology, Chiba University Hospital, Chiba, Japan,
,
Shunsuke FurutaDepartment of Allergy and Clinical Immunology, Chiba University Hospital, Chiba, Japan,
,
Timothy B. NiewoldDepartment of Immunology, Division of Rheumatology, Mayo Clinic, Rochester, MN, USA, and
&
Hiroshi NakajimaDepartment of Allergy and Clinical Immunology, Chiba University Hospital, Chiba, Japan,
show all
Pages 192-194 | Received 31 Mar 2016, Accepted 28 May 2016, Published online: 12 Jul 2016
 
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Abstract

Clinical manifestations of systemic lupus erythematosus (SLE) in female patients with polysomy X have been less characterized as compared to those in male patients. Here, we describe a 28-year-old woman with trisomy X (47,XXX) who developed SLE. She had polyarthritis, hemolytic anemia, and was positive for anti-nuclear and anti-dsDNA antibodies. We discuss the common SLE manifestations with female polysomy X and the possible link between the development of SLE and the presence of extra X-chromosomes.

Acknowledgments

We thank all staff in our hospital who gave care to the patient.

Funding

This research received no specific financial support.

Conflict of interest

Authors do not have conflicts of interest to report.

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