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Abstract
Objectives: Acute kidney injury (AKI) at onset of adult systemic lupus erythematosus (SLE) is a risk factor for end stage kidney disease (ESKD). However, data on childhood-onset lupus nephritis (LN) with AKI are scarce.
Methods: We retrospectively reviewed the complete files of pediatric SLE patients from 1995 to 2010. All patients underwent kidney biopsy promptly after diagnosis.
Results: Thirty-six patients (10 males and 26 females) were enrolled. Mean age at diagnosis and observation period were 11.6 ± 2.4 and 8.1 ± 4.4 years, respectively. Seven patients had AKI at onset of SLE. Compared with those without AKI, patients with AKI had significantly higher proportions of pathologically proliferative LN. Only one patient with AKI progressed to ESKD without complete recovery of renal function. Overall and renal survival rates were 100and 97.2%, respectively. There was no significant difference in estimated glomerular filtration rate at the final visit (85ml/min/1.73 m2 in the AKI group vs. 103.2 ml/min/1.73 m2 in the non-AKI group; p = .11).
Conclusion: Our study demonstrated favorable renal outcomes in childhood-onset LN with AKI in the near to midterm period. Inducing complete remission may be important for preserving renal function.
Acknowledgements
We thank Richard Robins, PhD, from Edanz Group (www.edanzediting.com/ac) for editing a draft of this manuscript.
Conflict of interests
Kazumoto Iijima reports grants from Astellas Pharma Inc. lecture and/or consulting fees from Pfizer Japan, Inc., Asahi Kasei Pharma Corp., Novartis Pharma K.K., Chugai Pharmaceutical Co., Ltd., Astellas Pharma Inc., KYORIN Pharmaceutical Co., Ltd., and Takeda Pharmaceutical Company Limited. All other authors have declared no conflicts of interest.