Near-infrared spectroscopy (NIRS) measured tissue oxygenation in neonates with gastroschisis: a pilot study

Abstract

Background

Management of gastroschisis involves either primary or staged closure. Bowel ischemia and abdominal compartment syndrome (ACS) are possible complications that can be related to a method of treatment. NIRS monitoring has never been applied in this group of patients and may allow for earlier detection of complications.

Objective

To assess near-infrared spectroscopy (NIRS) monitoring in neonates with gastroschisis for detecting changes in tissue oxygenation (rSO₂) related to bowel reductions or height of bowel in the silo and for detecting tissue ischemia.

Methods

Patients with gastroschisis and controls underwent continuous multi-channel assessment of oxygenation of the brain (CrSO₂), kidney (RrSO₂) and bowel (GrSO₂) in a prospective pilot study.

Results

Fifteen neonates were treated with primary closure (n = 3) or staged closure (n = 12); two had confirmed bowel ischemia, none developed ACS.

There was no significant correlation between height of the bowel and GrSO₂ at apex (p = .72) or base (p = .54) within the silo. During staged reductions there was a clinically non-significant change in RrSO₂ (Δ-2.5%, p = .04), but no significant changes in CrSO₂ (p = .11), and GrSO₂ of apex (p = .97) and base (p = .31). Patients with confirmed ischemia had GrSO₂ that were lower than controls.

Conclusions

Measuring GrSO₂ through a silo is feasible. Staged reduction seems safe based on NIRS measurements, with minimal effect of hydrostatic pressure on bowel oxygenation. NIRS was able to detect subtle changes in intra-abdominal renal perfusion during reduction and could differentiate healthy and ischemic bowel.

Keywords:

• Gastroschisis
• NIRS
• bowel oxygenation
• ischemia
• neonates

Disclosure statement

No potential conflict of interest was reported by the author(s).