Preliminary Validation for the “BJR method”—A Possible New Mathematical Approach to Methadone Conversion

Abstract

Methadone has been effectively utilized in the palliative care setting as a second-line agent for pain management in cancer patients with refractory pain, or in those who cannot tolerate other opioid medications. The lack of reliable dosing ratios, substantial interindividual variability in methadone pharmacodynamics, the potential for extensive drug interactions, and the high potency of methadone compared with other opioids all pose significant barriers to the use of this drug in routine practice. This article describes a novel approach to methadone conversion, with case studies providing preliminary validation.

Keywords:

• Ayonrinde
• equianalgesic
• methadone
• opioid conversion
• palliative
• pharmacokinetics
• Plonk

Acknowledgments

The authors wish to thank Brittany Werme, MSIV, and Misty Dockery, NP, for assistance in the preparation of this article.

Disclosure statement

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the article.