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Journal of Pain & Palliative Care Pharmacotherapy Volume 34, 2020 - Issue 1
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Calcitonin Gene-Related Peptide (CGRP) Antagonists and Their Use in Migraines

Brianna Henson Brianna Henson, PharmD, is with PGY-2 Pediatric Pharmacy Resident, Wake Forest Baptist Health Brenner Children’s Hospital, Winston-Salem, North Carolina, USA; Hanna Hollingsworth, PharmD, BCPS, is with Pain Clinical Pharmacy Specialist, Parkland Health and Hospital System, Dallas, Texas, USA; Erika Nevois, PharmD, is with CVS/Pharmacy, Springfield, Illinois, USA; Chris Herndon, PharmD, BCACP, is with School of Pharmacy, Southern Illinois University Edwardsville, Edwardsville, Illinois, USA
,
Hanna Hollingsworth Brianna Henson, PharmD, is with PGY-2 Pediatric Pharmacy Resident, Wake Forest Baptist Health Brenner Children’s Hospital, Winston-Salem, North Carolina, USA; Hanna Hollingsworth, PharmD, BCPS, is with Pain Clinical Pharmacy Specialist, Parkland Health and Hospital System, Dallas, Texas, USA; Erika Nevois, PharmD, is with CVS/Pharmacy, Springfield, Illinois, USA; Chris Herndon, PharmD, BCACP, is with School of Pharmacy, Southern Illinois University Edwardsville, Edwardsville, Illinois, USA
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Erika Nevois Brianna Henson, PharmD, is with PGY-2 Pediatric Pharmacy Resident, Wake Forest Baptist Health Brenner Children’s Hospital, Winston-Salem, North Carolina, USA; Hanna Hollingsworth, PharmD, BCPS, is with Pain Clinical Pharmacy Specialist, Parkland Health and Hospital System, Dallas, Texas, USA; Erika Nevois, PharmD, is with CVS/Pharmacy, Springfield, Illinois, USA; Chris Herndon, PharmD, BCACP, is with School of Pharmacy, Southern Illinois University Edwardsville, Edwardsville, Illinois, USA
&
Chris Herndon Brianna Henson, PharmD, is with PGY-2 Pediatric Pharmacy Resident, Wake Forest Baptist Health Brenner Children’s Hospital, Winston-Salem, North Carolina, USA; Hanna Hollingsworth, PharmD, BCPS, is with Pain Clinical Pharmacy Specialist, Parkland Health and Hospital System, Dallas, Texas, USA; Erika Nevois, PharmD, is with CVS/Pharmacy, Springfield, Illinois, USA; Chris Herndon, PharmD, BCACP, is with School of Pharmacy, Southern Illinois University Edwardsville, Edwardsville, Illinois, USACorrespondence[email protected]
ORCID Iconhttp://orcid.org/0000-0003-2387-415X
ORCID Icon
Pages 22-31 | Received 03 Mar 2019, Accepted 23 Oct 2019, Published online: 25 Nov 2019
 
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Abstract

Migraine is highly prevalent and associated with a large socio-economic burden in the United States. Current preventive medications have variable efficacy and their use is often limited by intolerable side effects. Calcitonin gene-related peptide (CGRP) has been identified as an integral part of migraine pathophysiology. There are currently seven CGRP antagonists under investigation, all of which are undergoing or have completed phase 3 clinical trials. Three of the investigated CGRP antagonists are approved for use within and outside of the United States. The trials have resulted in positive efficacy and safety data. The purpose of this review is to evaluate the seven CGRP antagonists and their future place in therapy.

Disclosure statement

Dr. Henson has no interests to disclose. Dr. Hollingsworth has no interests to disclose. Dr. Nevois has no interests to disclose. Dr. Herndon declares the following interests: Research support (NIDA, SAMHSA), Honoraria (ASHP, APhA, Pharmacy Times Continuing Education), Legal Consulting (US Attorney, Southern Illinois, TJ Preuss, Feirich, Mager, Green, Ryan), Travel support (Painweek).

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