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Fetal and Pediatric Pathology Volume 39, 2020 - Issue 6
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Association of Interleukin-10 -1082G > A Polymorphism with Susceptibility to Preeclampsia: A Systematic Review and Meta-Analysis Based on 21 Studies

Mehrnaz VeisianDepartment of Gynecology and Obstetrics, Isfahan University of Medical Sciences, Isfahan, Iran;
,
Razieh Sadat TabatabaeiDepartment of Gynecology and Obstetrics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran; Correspondence[email protected]
,
Atiyeh JavaheriDepartment of Gynecology and Obstetrics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran;
,
Hajar AbbasiDepartment of Gynecology and Obstetrics, Shahid Beheshti University of Medical Sciences, Tehran, Iran;
,
Erfaneh SalimiDepartment of Gynecology and Obstetrics, Shahid Beheshti University of Medical Sciences, Tehran, Iran;
,
Amaneh HadadanDepartment of Gynecology and Obstetrics, Shahid Beheshti University of Medical Sciences, Tehran, Iran;
,
Leila ZanbaghDepartment of Gynecology and Obstetrics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran;
,
Seyed Alireza DastgheibDepartment of Medical Genetics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran;
&
Hossein NeamatzadehDepartment of Medical Genetics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran; ;Mother and Newborn Health Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
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Pages 518-532 | Received 16 Sep 2019, Accepted 30 Sep 2019, Published online: 06 Nov 2019
 
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Abstract

Background: Previous studies have reported the association between IL-10 -1082 G > A polymorphism and preeclampsia risk, but the results remained controversial. Therefore, this meta-analysis was performed to evaluate the association of IL-10 -1082 G > A polymorphism with preeclampsia risk.

Methods: We searched PubMed, ISI Web of Knowledge and CNKI databases to identify eligible studies up to September 05, 2019.

Results: A total of 21 case-control studies with 3,510 cases and 5,874 controls were selected. The results revealed that IL-10 -1082 G > A polymorphism was significantly associated with an increased risk of preeclampsia under the recessive model (AA vs. AG + GG: OR = 1.191, 95% CI = 1.018–1.394, P = 0.029). Stratified analyses by ethnicity revealed a significantly increased risk of preeclampsia in Asian and mixed populations, but not in Caucasians. Moreover, there was a significant association among Chinese and Brazilian.

Conclusions: Our results showed that IL-10 -1082 G > A polymorphism was significantly associated with an increased risk of preeclampsia.

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