Effects of occupational exposure to trace levels of halogenated anesthetics on the liver, kidney, and oxidative stress parameters in operating room personnel

Abstract

This study was conducted to measure the concentration of halogenated anesthetics in breathing zone air of the personnel and evaluate their effects on hepatic and renal functions as well as oxidative stress parameters. Levels of these gases in air samples were lower than the national recommended exposure limits (50 ppm). Occupational exposure to anesthetic gases significantly induced oxidative stress in the operating room personnel, marked by increased plasma levels of transaminase enzymes accompanied by the marked decline of enzymatic and non-enzymatic antioxidant levels, and the rise of MDA levels (p < 0.05); these adverse effects would increase with increasing work experience.

KEYWORDS:

• Operating room
• anesthetic gases
• oxidative stress
• liver toxicity

Acknowledgments

The authors thank with utmost sincerely Clinical Research Development of Imam Khomeini Hospital, Urmia University of Medical Sciences, and the staff for their generous support and participation.

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This study was financially supported by Urmia University of Medical Sciences.