The effect of captopril on inflammation-induced liver injury in male rats

Abstract

Activation of macrophages-induced by lipopolysaccharide (LPS) is accompanied by the production of reactive oxygen species and inflammatory cytokines to induce hepatic injury. Renin–angiotensin system may play a role in liver damage. In the current study, the effect of captopril on the injury of inflammation-induced liver was investigated. The rats were divided into (1) Control, (2) LPS, and (3–5) LPS as well as 10, 50, or 100 mg/kg captopril for 2 weeks. Captopril decreased NO metabolites, IL-6, and MDA, while it increased CAT, SOD, and total thiol in the liver. Captopril also attenuated AST, ALT, and ALK-P, whereas it increased albumin and total protein in serum. As an ACE inhibitor, captopril improved liver function and attenuated inflammation and oxidative stress induced by LPS injection.

Keywords:

• Lipopolysaccharide
• liver
• captopril
• oxidative stress
• inflammation

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

The authors would like to thank the Vice Presidency of Isfahan (Khorasgan) Branch, Islamic Azad University, Isfahan, Iran, for the research financial support.