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Toxin Reviews Volume 40, 2021 - Issue 4
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Research Article

Impact of bee venom and melittin on apoptosis and biotransformation in colorectal carcinoma cell lines

Danijela D. Nikodijevića Department of Biology and Ecology, Faculty of Science, University of Kragujevac, Kragujevac, SerbiaORCID Iconhttps://orcid.org/0000-0002-6453-0313View further author information
ORCID Icon,
Milena G. Milutinovića Department of Biology and Ecology, Faculty of Science, University of Kragujevac, Kragujevac, SerbiaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-5075-5650View further author information
ORCID Icon,
Danijela M. Cvetkovića Department of Biology and Ecology, Faculty of Science, University of Kragujevac, Kragujevac, SerbiaORCID Iconhttps://orcid.org/0000-0001-7767-1345View further author information
ORCID Icon,
Maja Đ. Ćupurdijaa Department of Biology and Ecology, Faculty of Science, University of Kragujevac, Kragujevac, SerbiaORCID Iconhttps://orcid.org/0000-0001-7173-160XView further author information
ORCID Icon,
Milena M. Jovanovića Department of Biology and Ecology, Faculty of Science, University of Kragujevac, Kragujevac, SerbiaORCID Iconhttps://orcid.org/0000-0002-2003-8124View further author information
ORCID Icon,
Ivan V. Mrkićb Department of Biochemistry, Faculty of Chemistry, University of Belgrade, Belgrade, SerbiaORCID Iconhttps://orcid.org/0000-0002-0262-3741View further author information
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Marija Đ. Jankulović-Gavrovićb Department of Biochemistry, Faculty of Chemistry, University of Belgrade, Belgrade, SerbiaORCID Iconhttps://orcid.org/0000-0002-8591-4391View further author information
ORCID Icon &
Snežana D. Markovića Department of Biology and Ecology, Faculty of Science, University of Kragujevac, Kragujevac, SerbiaORCID Iconhttps://orcid.org/0000-0002-3892-8977View further author information
ORCID Icon show all
Pages 1272-1279 | Received 13 Feb 2019, Accepted 08 Oct 2019, Published online: 24 Oct 2019
 
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Abstract

This study provides data about anticancer properties of bee venom and its dominant compound, melittin on colorectal carcinoma cells (HCT-116 and SW-480) in regard to their proapoptotic activity and expression of genes involved in biotransformation process. Based on results, they are strong cytotoxins, where the melittin showed also selectivity against cancer cells compared to normal, HaCat. They induce proapoptotic activity by affecting apoptosis signaling molecules (Fas receptors, caspase 9, and members of Bcl-2 family of proteins) and mainly suppress expression of genes involved in their biotransformation, suggesting their ability to develop the resistance of colorectal cancer cells.

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was supported by the Ministry of Education, Science and Technological Development of the Republic of Serbia [projects III 41010 and OI 172049].

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