Levothyroxine therapy attenuates anxiety-like states induced by mild chronically of neonatal hypothyroidism in both male and female rats

Abstract

Subclinical hypothyroidism tends to be more prevalent due to having a deficiency in iodine intake, which could lead to it. The role of sex differentiation in the susceptibility for anxiety-like behaviors of adult rats with mild neonatal hypothyroidism and then levothyroxine therapy is aimed to be investigated. Data showed that in both genders, reduced social performance and increased anxiety-like behaviors were revealed in a dose-dependent manner to propylthiouracil exposure in hypothyroid groups and levothyroxine therapy reversed the impairment performance and increased anxiety-like in the behavioral tests. Therefore, levothyroxine therapy can also be used as therapeutic methods for adult subject treatment.

Keywords:

• Hypothyroidism
• levothyroxine
• anxiety
• gender
• rat

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

This study is extracted from the thesis done by Mahdieh Taheri affiliated by Kerman Neuroscience Research Center [grant: EC/KNRC/95–12].