Toxins mechanism in instigating hepatotoxicity

Abstract

Myriad of therapeutic drugs used in clinical practice have led to hepatotoxicity reporting more than 1,100 pharmaceutical and chemical products with liver injury. Drug-induced liver damage reports for 7% of adverse reactions, 2% jaundice, 1% acute liver failure, and more acute hepatitis and account for approximately 40,000 deaths per annum in 17 countries. Considering the prominence of drug-induced hepatotoxicity, this review focuses on providing an overview of the plausible mechanisms of action of various intrinsic and idiosyncratic hepatotoxic drugs that involve various molecular and cellular elements in hepatotoxicity and cell death. Also, we discussed their hepatotoxicity control treatments.

Keywords:

• Hepatotoxicity
• intrinsic
• idiosyncratic
• CYP450
• immune response
• treatment

Acknowledgements

The authors express their gratitude to Vellore Institute of Technology for rendering the essential facilities.

Disclosure statement

No potential conflict of interest was reported by the author(s).