A comprehensive review on transdermal patches as an efficient approach for the delivery of drug

ABSTRACT

In past years, various studies have considered transdermal drug delivery system for improving patient compliance. One approach to deliver drug via transdermal route is transdermal patch. These patches include single-layer drug in adhesive patches and micro reservoir transdermal patch & matrix system. Acrylic-acid, hydroxypropyl methylcellulose (HPMC) and polyethylene glycol are commonly used polymers for manufacturing of transdermal patches. Characterization of patches includes patch thickness, weight uniformity, irritation studies, in-vitro drug release and permeation studies. This review summarizes various polymers, types of transdermal patches and evaluation of transdermal patches based on up-to-date data extracted from reputed journals and official websites.

Graphical abstract

KEYWORDS:

• Characterization
• drug hydrolysis
• skin irritation study
• transdermal drug delivery system
• transdermal patch

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

The authors reported there is no funding associated with the work featured in this article.

Notes on contributors

Ansa Ashfaq

Ansa Ashfaq, She is a Researcher in Faculty of Pharmaceutical Sciences, University of Central Punjab, Lahore, Pakistan.

Tehseen Riaz

Tehseen Riaz, She is a Senior Lecturer in Faculty of Pharmaceutical Sciences, University of Central Punjab, Lahore, Pakistan.

Muhammad Ahsan Waqar

Muhammad Ahsan Waqar, He is a Lecturer in Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Lahore University of Biological & Applied Sciences, Lahore, Pakistan.

Muhammad Zaman

Muhammad Zaman, He is an Associate Professor in Faculty of Pharmaceutical Sciences, University of Central Punjab, Lahore, Pakistan.

Imtiaz Majeed

Imtiaz Majeed, He is an Associate Professor in Faculty of Pharmaceutical Sciences, University of Central Punjab, Lahore, Pakistan.