Serum IL 6 and umbilical artery Doppler indices in pre-eclamptic patients

Peer review under responsibility of Alexandria University Faculty of Medicine.

The research protocol was approved by our institutional Ethics Committee before the study began. A Written informed consent for participation in the study was taken from all recruited women.

Available online 7 March 2016

Figures & data

Table 1 Comparison between the different studied groups according to serum IL6.

	Control (Group C)	Mild PET (Group B)	Severe PET (Group A)	^KWp
IL 6
Range	0.62–0.82	0.75–1.18	1.43–1.79	<0.001^⁎
Mean ± SD	0.71 ± 0.06	0.97 ± 0.14	1.67 ± 0.09
Median	0.72	0.97	1.69
p1		^MWp < 0.001^⁎	^MWp < 0.001^⁎
p2			^MWp < 0.001^⁎

p₁: p value between control and each other group.

p₂: p value between Mild PET and severe PET group.

^KWp: p value for Kruskal Wallis test between the three studied groups.

^MWp: p value for Mann–Whitney U test.

⁎ Statistically significant at p ⩽ 0.05.

Table 2 Comparison between the different studied groups according to RI and PI.

	Control	Mild PET	Severe PET	Test of sig
RI
Range	0.52–0.66	0.62–0.82	0.73–0.86	p < 0.001^⁎
Mean ± SD	0.59 ± 0.05	0.70 ± 0.05	0.81 ± 0.04
Median	0.58	0.69	0.82
p1		^LSDp < 0.001^⁎	^LSDp < 0.001^⁎
p2			^LSDp < 0.001^⁎
PI
Range	0.74–1.17	0.74–1.67	1.54–1.99	^KWp < 0.001^⁎
Mean ± SD	0.94 ± 0.16	1.04 ± 0.22	1.78 ± 0.13
Median	0.93	0.98	1.80
p1		^MWp = 0.065	^MWp < 0.001^⁎
p2			^MWp < 0.001^⁎

p₁: p value between control and each other group.

p₂: p value between Mild PET and severe PET group.

p: p value for test (ANOVA).

^LSDp: p value of Post Hoc test (LSD).

^KWp: p value for Kruskal Wallis test between the three studied groups.

^MWp: p value for Mann–Whitney U test.

⁎ Statistically significant at p ⩽ 0.05.

Figure 1 Correlation between IL6 and RI in the three studied groups.

Table 3 Correlation between IL6, PI, S/D ratio and RI in the three studied groups.

		IL6
		Control	Mild PET	Severe PET
PI	Rho	−0.416	−0.081	0.264
	p	0.068	0.619	0.100
S/D ratio	Rho	−0.137	−0.066	0.377^⁎
	p	0.564	0.686	0.017
RI^∗	r	−0.133	−0.085	0.346^⁎
	p	0.577	0.601	0.029

rho (ρ): Spearman coefficient.

r: Pearson coefficient.

RI^∗: The correlation was done after logarithmic normalization of IL6.

⁎ Statistically significant at p ⩽ 0.05.

Figure 2 ROC curve for IL6.

Table 4 Agreement (sensitivity, specificity and accuracy) for IL6.

		Control	Cases	Sensitivity	Specificity	PPV	NPV	Accuracy
IL6	⩽0.82	20	10	87.50	100.0	100.0	66.67	90.0
	>0.82	0	70