Pediatric reference intervals for serum folate and cobalamin based on a European population without exposure to folic acid fortification

Figures & data

Figure 1. (A, B) Scatter plots showing trends for individual gender separated results for folate (A) and cobalamin (B) with age.

Table 1. Age- and gender specific pediatric reference interval limits for serum folate (nmol/L).

Age	Sex	Lower	Upper	CI lower	CI upper	n	Suggested
2 mo–1.99 yrs	FM	20.97	>45.40	16.85–23.32	NA	349	21–>45
	F	21.28	>45.40	13.08–24.93	NA	161	NGP
	M	20.75	>45.40	14.87–23.20	NA	188	NGP
2–4.99 yrs	FM	12.24	>45.40	10.87–14.60	NA	285	12–>45
	F	11.93	>45.40	7.418–15.68	NA	131	NGP
	M	12.19	>45.40	10.30–14.12	NA	154	NGP
5–9.99 yrs	FM	11.49	>45.40	10.24–12.31	NA	729	10–>45
	F	11.04	>45.40	9.926–13.80	NA	335	NGP
	M	11.40	>45.40	10.25–12.27	NA	394	NGP
10–17.99 yrs	FM	7.234	39.59	6.917–8.171	38.15–41.93	994	7.2–>45
	F	7.600	39.77	7.122–8.592	36.44–42.62	510	NGP
	M	6.851	38.89	6.301–8.000	37.45–42.07	484	NGP

NA: not applicable, CI: 0.90-confidence interval, NGP: no gender partition.

Table 2. Age- and gender specific pediatric reference interval limits for cobalamin (pmol/L).

Age	Sex	Lower	Upper	CI lower	CI upper	n	Suggested
2 mo–0.99 yrs	FM	126.2	723.8	108.7–134.9	633.7–896.2	272	GP
	F	127.0	802.0	86.4–136.1	633.7–977.4	125	130–800
	M	120.6	668.2	108.0–137.2	609.5–1013	147	120–670
1–2.99 yrs	FM	161.7	698.2	137.9–189.2	675.9–832.7	174	GP
	F	162.0	806.4	NA	NA	79	160-810
	M	156.6	691.4	NA	NA	96	160–690
3–5.99 yrs	FM	245.9	883.0	210.7–269.2	832.2–918.4	325	GP
	F	264.1	833.5	205.3–302.1	766.1–904.9	153	260–830
	M	240.8	917.5	198.0–265.8	864.8–1087	172	240–920
6–11.99 yrs	FM	232.6	785.3	214.7–247.0	755.2–849.8	911	215–790
	F	237.2	779.7	219.6–258.6	741.3–894.7	420	NGP
	M	229.0	799.4	203.3–247.0	718.6–880.8	491	NGP
12–17.99 yrs	FM	174.0	673.4	158.8–182.0	632.3–739.4	692	GP
	F	177.2	752.0	148.3–186.9	647.0–802.9	370	180–750
	M	172.2	610.6	154.7–185.3	571.4–678.3	322	170–610

NA: not applicable, CI: 0.90-confidence interval, NGP: no gender partition, GP: gender partition.