Efficacy of blood parameters in predicting the severity of gestational hypertension and preeclampsia

Figures & data

Figure 1. Flow diagram of the study.

Table 1. Comparison of the study groups by their general demographic and clinical characteristics.

	Control n = 792	GHT n = 641	PE n = 208	SPE n = 364
Age, mean ± SD	27.0 ± 5.3*	30.0 ± 6.4*	28.0 ± 6.1*	30.0 ± 6.6*
BMI, mean ± SD	28.4 ± 4.1*	32.5 ± 5.4*	32.7 ± 6.0*	32.6 ± 5.7*
Gravida, median (IQR)	2 (1–3) *	2 (1–4) *	2 (1–3) *	2 (1–3) *
Gestational week at hospitalisation, mean ± SD	37.9 ± 3.6*	36.6 ± 3.8*	34.8 ± 4.0*	35.1 ± 3.9*
SBP at hospitalisation, mean ± SD	105.0 ± 4.9*	144.0 ± 6.5*	147.0 ± 7.3*	165.0 ± 15.3*
DBP at hospitalisation, mean ± SD	73.0 ± 1.6*	94.0 ± 6.0*	95.0 ± 6.6*	103.0 ± 10.0*
MAP at hospitalisation, mean ± SD	83.0 ± 1.5*	110.0 ± 5.2*	112.0 ± 5.7*	124.0 ± 10.4*

IQR: interquartile percentile; SD: standard deviation; SBP: systolic blood pressure; DBP: diastolic blood pressure; MAP: mean arterial pressure; GHT: gestational hypertension; PE: preeclampsia; SPE: severe preeclampsia; BMI: body mass index.

*p-value < 0.001.

Table 2. Comparison of the study groups in terms of tested laboratory parameters at diagnosis.

	Control n = 792	GHT n = 641	PE n = 208	SPE n = 364	p-value
NLR, mean ± SD	4.51 ± 1.89	4.16 ± 1.63	3.85 ± 1.56	4.57 ± 3.03	<0.001*
PLR, mean ± SD	132.5 ± 59.5	136.6 ± 47.1	130.4 ± 55.7	121.6 ± 52.9	<0.001*
PDW, mean ± SD	54.2 ± 7.4	55.3 ± 8.3	55.2 ± 7.8	56.7 ± 8.8	<0.001*
DNI, mean ± SD	–2.46 ± 3.91	–3.02 ± 6.00	–3.03 ± 3.67	–2.83 ± 3.60	0.125
APRI, mean ± SD	0.23 ± 0.09	0.23 ± 0.11	0.24 ± 0.15	1.41 ± 9.36	<0.001*

GHT: gestational hypertension; PE: preeclampsia; SPE: severe preeclampsia; NLR: neutrophil lymphocyte ratio; PLR: platelet lymphocyte ratio; PDW: platelet distribution width; DNI: delta neutrophil index; APRI: aspartate aminotransferase platelet ratio index; SD: standard deviation.

Figure 2. ROC analysis curve for PDW between the control and GHT groups.

Figure 3. ROC analysis curve for NLR between the control and GHT groups.

Table 3. Comparison of the study groups in terms of available laboratory parameters by 20^th weeks of gestation.

	Control n = 363	GHT n = 283	PE n = 80	SPE n = 143	p-value
NLR, mean ± SD	3.20 ± 1.22	3.39 ± 1.99	3.17 ± 1.37	3.17 ± 1.05	0.294
PLR, mean ± SD	146.2 ± 62.5	157.1 ± 119.3	150.6 ± 44.8	146.3 ± 43.2	0.365
PDW, mean ± SD	48.2 ± 6.2	49.7 ± 7.1	47.1 ± 7.6	49.5 ± 6.9	0.003*
DNI, mean ± SD	–4.1 ± 6.0	–3.0 ± 4.9	–3.2 ± 4.2	–3.8 ± 6.9	0.105
APRI, mean ± SD	0.20 ± 0.09	0.19 ± 0.06	0.19 ± 0.11	0.18 ± 0.07	0.034*

GHT: gestational hypertension; PE: preeclampsia; SPE: severe preeclampsia; NLR: neutrophil lymphocyte ratio; PLR: platelet lymphocyte ratio; PDW: platelet distribution width; DNI: delta neutrophil index; APRI: aspartate aminotransferase platelet ratio index; SD: standard deviation.

Data availability statement

Data are openly available in a public repository that issues datasets with DOIs.