Preoperative clinical characteristics for differentiating malignant transformation from torsion of mature cystic teratoma

Figures & data

Figure 1. Flowchart of patients in this study.

Figure 2. Kaplan–Meier survival curves for overall survival (OS) in patients with SCC and non-SCC, which showed that SCC were significantly associated with shorter OS.

Table 1. Baseline characteristic of patients with MT-MCT and torsion.

Characteristics	MT-MCT group (n = 27)	Torsion group (n = 125)	p Value
Age (years)	54.81 ± 14.42	31.66 ± 14.83	<0.001
Size (mm)	122.59 ± 53.23	101.72 ± 34.55	0.011
AFP (U/mL)	27.24 ± 122.17	5.48 ± 22.40	0.073
CEA (U/mL)	15.80 ± 31.83	1.72 ± 2.27	<0.001
CA125 (U/mL)	154.82 ± 369.08	31.85 ± 31.54	<0.001
CA19-9 (U/mL)	176.22 ± 577.56	122.12 ± 481.62	0.155
PLT count (×10^9 /L)	316.19 ± 118.25	242.70 ± 64.87	<0.001
Haemoglobin (g/L)	119.37 ± 14.47	122.94 ± 19.82	0.385
Albumin (g/L)	39.40 ± 6.15	44.05 ± 4.27	<0.001
NLR	4.23 ± 2.97	6.93 ± 2.97	0.023
PLR	223.30 ± 110.76	203.43 ± 141.65	0.495
MLR	0.37 ± 1.85	0.95 ± 3.78	0.428

AFP: Alpha fetoprotein; CEA: carcinoembryonic antigen; PLT: platelet; NLR: neutrophil-to-lymphocyte ratio; PLR: platelet to lymphocyte ratio; MLR: lymphocyte to monocyte ratio

Table 2. Univariate and multivariate analysis.

Characters	Univariate analysis		Multivariate analysis
	OR (95% CI)	p Value	OR (95% CI)	p Value
Age (years)	1.055 (1.017–1.096)	<0.001	1.076 (1.041–1.111)	<0.001
Size (mm)	1.013 (1.003–1.024)	0.015	–
CEA (U/mL)	1.224 (1.033–1.450)	0.001	–
CA125 (U/mL)	1.012 (1.004–1.019)	0.003	–
PLT (×10^9 /L)	1.013 (1.007–1.019)	<0.001	1.012 (1.005–1.020)	0.001
Albumin (g/L)	0.834 (0.762–0.913)	<0.001
NLR	0.845 (0.729–0.978)	0.024	0.794 (0.647–0.915)	0.027

CEA: carcinoembryonic antigen; PLT: platelet; NLR: NLR: neutrophil-to-lymphocyte ratio

Figure 3. Receiver-operating curve of preoperative markers to diagnose MT-MCT.

Table 3. The diagnostic value of preoperative markers for MT-MCT.

Marker	Cut-off value	Sensitivity %	Specificity %	AUC (95% CI)	p Value
Age (years)	38.50	85.2	74.4	0.869 (0.808–0.929)	<0.001
PLT (×10^9 /L)	317.50	44.4	89.6	0.711 (0.591–0.831)	0001
NLR	3.31	73.6	59.3	0.657 (0.554–0.761)	0.010
Combination^a	NA	92.6	80.8	0.921 (0.877–0.964)	<0.001

PLT: platelet; NLR: neutrophil-to-lymphocyte ratio; NA: not applicable

^aComprising measurement of age, serum platelet count and serum neutrophil-to-lymphocyte ratio.