The rs2275913 polymorphism of the interleukin-17A gene is associated with the risk of ovarian endometriosis

Figures & data

Table 1. Clinical characteristics of women with ovarian endometriosis and controls.

Variable	Cases (n = 316)	Controls (n = 328)	p
Age, years (mean ± SD)	34.3 ± 7.8	35.1 ± 8.1	.204
BMI, kg/m^2 (mean ± SD)	23.2 ± 3.0	25.4 ± 2.8	<.001
Age at menarche, years (mean ± SD)	14.1 ± 1.5	14.2 ± 1.6	.366
Duration of menstruation, days (mean ± SD)	5.8 ± 1.2	5.2 ± 1.2	<.001
Interval of menstruation, days (mean ± SD)	28.4 ± 2.6	29.0 ± 2.9	.011
Infertility, n (%)
Yes	95 (30.1)	53 (16.2)
No	221 (69.9)	275 (83.8)	<.001
Smoking history, n (%)
Yes	31 (9.8)	22 (6.7)
No	285 (90.2)	306 (93.3)	.152

BMI: body mass index.

Table 2. Association of rs2275913 and rs3748067 with the risk of ovarian endometriosis.

Genotypes	Controls (%) n = 328	Cases (%) n = 316	p	OR (95% CI)	p^a	OR (95% CI)^a
rs2275913
GG	160 (48.8)	126 (39.9)		Reference		Reference
GA	139 (42.4)	138 (43.7)	.171	1.26 (0.91–1.76)	.381	1.17 (0.82–1.67)
AA	29 (8.8)	52 (16.5)	.001	2.28 (1.37–3.80)	.006	2.15 (1.25–3.70)
rs3748067
CC	279 (85.1)	257 (81.3)		Reference		Reference
CT + TT	49 (14.9)	59 (18.7)	.205	1.31 (0.86–1.98)	.162	1.37 (0.88–2.14)

OR: odds ratio; CI: confidence interval.

^a Adjusted for body mass index.

Figure 1. The mRNA expression of IL-17A in the 55 ectopic endometrial tissues and 26 eutopic endometrial tissues from patients with ovarian endometriosis and 36 healthy endometrial tissue samples from control subjects. Data were expressed as median with interquartile range, and analysed by Mann–Whitney’s U-test with Bonferroni’s correction.

Figure 2. Effect of IL-17A polymorphisms on the expression of IL-17A in the ectopic endometrium of ovarian endometriosis patients. Data were expressed as median with interquartile range, and analysed by the Mann–Whitney U-test with Bonferroni’s correction. A: rs2275913; B: rs3748067.

Data availability statement

All data included in this study are available upon request by contact with the corresponding author.