Prediction of embryo euploidy and pregnancy outcome by blastocyst morphology and development speed for women receiving single embryo transfer

Figures & data

Figure 1. Study flowchart.

PGT, preimplantation genetic testing.

Table 1. Clinicodemographic characteristics of patients with oocyte retrieval.

Variables	Data
No. of cycles	155
Age (years)	32 (27, 36)
No. of ovarian stimulation cycles	1 (1, 2)
No. of spontaneous miscarriage	0 (0, 1)
BMI (kg/cm^2)	21.4 (20.1, 23.6)
Ovarian stimulation protocol
GnRH-agonist protocols (No. %)	111 (72.5%)
No. of GnRH-antagonist protocols (No. %)	40 (26.1%)
No. of Other stimulation protocols (No. %)	2 (1.3%)
No. of oocytes	17 (10, 24)
Fertilisation rate (%)	71.9 (66.3, 78.6)
No. of D3 embryos	13 (8, 17)
No. of blastocyst	7 (3, 11)
D5 blastocysts	4 (2, 7)
D6 blastocysts	3 (1, 4)
Blastocyst formation rate (%)	53.2 (43.7, 68.8)

Continuous variables expressed as median (25% percentile, 75% percentile) and categorical variables as number (%).

BMI, body mass index; GnRH, gonadotropin-releasing hormone.

Table 2. Clinicodemographic characteristics of patients receiving blastocyst transfer.

Variables	Data
No. of cycles	154
Age (years)	31 (26, 36)
No. of embryo transfer cycles	1 (1, 1)
No. of spontaneous miscarriage	0 (0, 1)
BMI (kg/cm^2)	21.6 (20.2, 23.4)
D5 blastocyst transfer cycles	106 (70.2%)
D6 blastocyst transfer cycles	45 (29.8%)

Con Continuous variables expressed as median (25% percentile, 75% percentile) and categorical variables as number (%).

BMI, body mass index.

Figure 2. Euploidy rate according to blastocyst development speed and morphology grade.

Figure 3. Associations of developmental speed and morphological grade with pregnancy outcome after euploid blastocyst transfer.

Table 3. Comparison of pregnancy outcomes between D5 and D6 euploidy transfers with different morphological grades.

Variables	D5 high-grade (n = 88)	D5 non-high-grade (n = 18)	D6 high-grade (n = 29)	D6 non-high-grade (n = 19)
Age (years)	32 (27, 36)	29 (25, 35)	31 (26, 35)	31 (27, 35)
Clinical pregnancy (n, %)	61 (69.3%)	9 (50.0%)	17 (58.6%)	10 (52.6%)
Ongoing pregnancy (n, %)	58 (65.9%)	8 (44.4%)	13 (44.8%)	8 (42.1%)
Total clinical pregnancy (n, %)	70/106 (66.0%)		27/48 (56.3%)
Total ongoing pregnancy (n, %)	66/106 (62.3%)		21/48 (43.8%)

Continuous variables expressed as median (25% percentile, 75% percentile) and categorical variables as number (%).

Data availability statement

Data supporting the results of this study will be shared upon reasonable request to the corresponding author.