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Journal of Microencapsulation
Micro and Nano Carriers
Volume 25, 2008 - Issue 6
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Research Article

Biocompatible chitosan-DNAzyme nanoparticle exhibits enhanced biological activity

Dr. Crispin R. Dass Department of Orthopaedics and University of Melbourne Department of Surgery, St. Vincent's Hospital, VIC, Australia
,
Anna M. Friedhuber Department of Pathology, University of Melbourne, VIC, Australia
,
Levon M. Khachigian Centre for Vascular Research, UNSW and Prince of Wales Hospital, NSW, Australia
,
Dave E. Dunstan Department of Chemical and Biomolecular Engineering, University of Melbourne, VIC, Australia
&
Peter F. M. Choong Department of Orthopaedics and University of Melbourne Department of Surgery, St. Vincent's Hospital, VIC, Australia; Sarcoma Service, Peter MacCallum Cancer Institute, VIC, Australia
Pages 421-425 | Received 16 Nov 2007, Accepted 04 Mar 2008, Published online: 08 Oct 2008
 
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Abstract

DNAzymes are oligonucleotides capable of specific catalysis of target mRNA. To date, a delivery vehicle for DNAzymes has not been developed. Chitosan is a biomaterial obtained abundantly in nature. A biocompatible c-jun (an oncogene) DNAzyme nanoparticle formulated from chitosan was found to be more active against osteosarcoma (bone cancer) cells, inducing apoptotic cell death in these cells. The formulation was stable in serum for a week and at room temperature for a month. Clinically, knockdown of c-jun gene expression with chitosan nanobiotechnology may improve treatment outcome for tumours growing in bone.

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