Study of heat shock response of human umbilical vein endothelial cells (HUVECs) using cDNA microarray

Figures & data

Table I.  Number of genes changed after heat treatment at the two temperatures (44°C and 55°C), respectively.

	Up-regulated	Down-regulated	Unchanged
44°C	1115	333	949
55°C	1669	287	1311

Table II.  Orthogonal analyses of regulated genes at 44°C and 55°C. The number inside circle stands for the group number. The number in the table stands for the number of genes.

	44°C
55°C	Up-regulated	Down-regulated	Unchanged
Up-regulated	A 406	B  2	C  57
Down-regulated	D  2	E 76	F   9
Unchanged	G  24	H 51	I   400

Table III.  Relatively enriched functional categories of each group in Table II.

Functional categories	No. of genes	Fisher's exact test
Group A
Cell communication	55	0.0131
Signal transduction	44	0.048
Receptor signaling protein activity	6	0.085
Organismal movement	6	0.0891
Detection of external stimulus	6	0.0891
Group C
Regulation of cell cycle	3	0.00754
Metabolism	9	0.0416
Biosynthesis	4	0.0201
Protein biosynthesis	3	0.0313
Cell cycle	3	0.0529
Nucleobase, nucleoside, nucleotide   and nucleic acid metabolism	5	0.0961
Macromolecule biosynthesis	3	0.0745
Group E
Metal ion binding	8	0.013
Cytoplasm	16	0.0263
Oxidoreductase activity	5	0.0298
Mitochondrion	5	0.0464
Calcium ion binding	4	0.0726
Lipid metabolism	4	0.096
Response to abiotic stimulus	3	0.0804
Group F
Hydrolase activity	6	0.0737
Membrane fraction	3	0.0757
Group G
Cytosol	7	0.000704
Large ribosomal subunit	4	0.00019
Cytosolic ribosome (sensu Eukarya)	4	0.000869
Ribosome	5	0.0033
Structural constituent of ribosome	5	0.00371
Cytoplasm	18	0.013
Structural molecule activity	7	0.0101
Cytosolic large ribosomal   subunit (sensu Eukarya)	3	0.00169
Protein binding	10	0.0436
Chromatin modification	3	0.0137
Protein biosynthesis	6	0.0437
Protein metabolism	12	0.0848
Cell fraction	5	0.0663
DNA packaging	3	0.0402
Chromosome organization and   biogenesis (sensu Eukarya)	3	0.0402
Establishment and/or maintenance   of chromatin architecture	3	0.0402
Nuclear organization and biogenesis	3	0.0402
Ribonucleoprotein complex	5	0.0806
Calcium ion binding	4	0.0726
Regulation of transcription   from Pol II promoter	3	0.059
Chaperone activity	3	0.0668

Figure 1. Comparisons between microarray results and real-time PCR of two randomly chosen genes: DNAJB1 and CCND2.

Cell communication.

Uniqid	Locuslink	Gene name	Classification	Locuslink classifications
AB002354	9842	adapter protein 162	biological_process	intracellular signaling cascade
AB037818	56995	tubby like protein 4	biological_process	cellular_component unknown; intracellular signaling cascade; regulation of transcription, DNA-dependent; transcription factor activity
AB044807	10207	InaD-like protein	biological_process	cellular_component unknown; intracellular signaling cascade; protein binding
AB052751	8313	axin 2 (conductin, axil)	biological_process	development; frizzled signaling pathway; intracellular; signal transducer activity; signal transduction
AB065846	259249	G protein-coupled receptor MRGX1	biological_process	G-protein coupled receptor protein signaling pathway; integral to membrane; receptor activity; rhodopsin-like receptor activity
AF034833	3679	integrin, alpha 7	biological_process	cell-matrix adhesion; cellular morphogenesis; homophilic cell adhesion; integrin complex; integrin-mediated signaling pathway; muscle development; protein binding; receptor activity
AF053356	2056	erythropoietin	biological_process	cell-cell signaling; circulation; development; erythropoietin receptor binding; extracellular space; hormone activity; response to stress; signal transduction
AF053356	2783	guanine nucleotide binding protein (G protein), beta polypeptide 2	biological_process	G-protein coupled receptor protein signaling pathway; heterotrimeric G-protein GTPase activity; heterotrimeric G-protein complex; signal transducer activity; signal transduction
AF053356	7455	zonadhesin	biological_process	apical plasma membrane; binding of sperm to zona pellucida; cell recognition; cell-cell adhesion; integral to membrane; protein binding
AF061943	51677	prostate derived STE20-like kinase PSK	biological_process	ATP binding; actin cytoskeleton organization and biogenesis; activation of MAPKK; apoptosis; cell migration; cytoplasmic vesicle; focal adhesion formation; positive regulation of JNK cascade; protein amino acid phosphorylation; protein serine/threonine kinase activity; protein-membrane targeting; regulation of cell growth; regulation of cell shape; response to stress; transferase activity
AF120324	26230	T-cell lymphoma invasion and metastasis 2	biological_process	guanyl-nucleotide exchange factor activity; intracellular signaling cascade; protein binding; receptor signaling protein activity
AF130420	9372	MAD, mothers against decapentaplegic homolog (Drosophila) interacting protein, receptor activation anchor	biological_process	SMAD protein heteromerization; SMAD protein nuclear translocation; cytoplasm; early endosome; endocytosis; protein binding; receptor activity; serine-type peptidase activity; transforming growth factor beta receptor complex assembly; zinc ion binding
AF141901	22941	SH3 and multiple ankyrin repeat domains 2	biological_process	GKAP/Homer scaffold activity; cellular_component unknown; intracellular signaling cascade; protein binding
AF172264	23043	Traf2 and NCK interacting kinase	biological_process	ATP binding; protein amino acid phosphorylation; protein kinase cascade; protein serine/threonine kinase activity; regulation of translation; response to stress; small GTPase regulatory/interacting protein activity; transferase activity
AF222689	3276	HMT1 hnRNP methyltransferase-like 2 (S. cerevisiae)	biological_process	N-methyltransferase activity; S-adenosylmethionine-dependent methyltransferase activity; cell surface receptor linked signal transduction; cytoplasm; defense response; nucleus; protein amino acid methylation; transferase activity
AF227129	50834	taste receptor, type 2, member 1	biological_process	G-protein coupled receptor activity; G-protein coupled receptor protein signaling pathway; biological_process unknown; chemosensory behavior; integral to membrane; receptor activity; taste receptor activity
AF236083	10886	G protein-coupled receptor 74	biological_process	G-protein coupled receptor activity; G-protein coupled receptor protein signaling pathway; cell growth and/or maintenance; detection of abiotic stimulus; integral to plasma membrane; neuropeptide receptor activity; rhodopsin-like receptor activity
AF237775	2872	MAP kinase-interacting serine/threonine kinase 2	biological_process	ATP binding; protein amino acid phosphorylation; protein kinase cascade; protein serine/threonine kinase activity; regulation of protein biosynthesis; regulation of translation; response to stress; transferase activity
AF258564	7410	vav 2 oncogene	biological_process	diacylglycerol binding; guanyl-nucleotide exchange factor activity; intracellular signaling cascade
AF276423	55914	erbb2 interacting protein	biological_process	Neu/ErbB-2 receptor binding; basal plasma membrane; basal protein localization; cell adhesion; cell cycle; cell growth; cytoplasm; epidermal growth factor receptor signaling pathway; establishment and/or maintenance of epithelial cell polarity; hemidesmosome; integrin binding; integrin-mediated signaling pathway; intermediate filament cytoskeleton organization and biogenesis; nucleus; protein binding; structural constituent of cytoskeleton
AF336797	3782	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3	biological_process	calcium-activated potassium channel activity; calmodulin binding; integral to membrane; ion channel activity; ion transport; membrane fraction; neurogenesis; potassium ion transport; small conductance calcium-activated potassium channel activity; synaptic transmission; voltage-gated potassium channel complex
AF420474	5597	mitogen-activated protein kinase 6	biological_process	ATP binding; MAP kinase activity; cell cycle; protein amino acid phosphorylation; protein serine/threonine kinase activity; signal transduction; transferase activity
AJ242544	4585	mucin 4, tracheobronchial	biological_process	Neu/ErbB-2 receptor binding; biological_process unknown; cell-matrix adhesion; extracellular matrix structural constituent; integral to plasma membrane; membrane; molecular_function unknown
AJ295237	57053	cholinergic receptor, nicotinic, alpha polypeptide 10	biological_process	extracellular ligand-gated ion channel activity; integral to membrane; ion channel activity; ion transport; neurotransmitter receptor activity; nicotinic acetylcholine-activated cation-selective channel activity; receptor binding; regulation of cell proliferation; synaptic transmission; synaptic transmission, cholinergic
AK000814	8681	phospholipase A2, group IVB (cytosolic)	biological_process	arachidonic acid metabolism; calcium ion binding; calcium-dependent phospholipase A2 activity; calcium-dependent phospholipid binding; calcium-mediated signaling; cytosol; extracellular; glycerophospholipid catabolism; inflammatory response; parturition; phospholipase activity
AK027377	59352	leucine-rich repeat-containing G protein-coupled receptor 6	biological_process	G-protein coupled receptor protein signaling pathway; integral to membrane; protein-hormone receptor activity
AK092864	64759	tensin-like SH2 domain-containing 1	biological_process	intracellular signaling cascade; phosphoprotein phosphatase activity; protein amino acid dephosphorylation
AY046538	8601	regulator of G-protein signalling 20	biological_process	GTPase activator activity; membrane; protein binding; regulation of G-protein coupled receptor protein signaling pathway; signal transducer activity; signal transduction
BC000043	379	ADP-ribosylation factor 4-like	biological_process	ARF small monomeric GTPase activity; GTP binding; nucleus; protein secretion; small GTPase mediated signal transduction
BC000493	1819	developmentally regulated GTP binding protein 2	biological_process	GTP binding; cell growth and/or maintenance; signal transduction
BC002392	4354	membrane protein, palmitoylated 1, 55 kDa	biological_process	guanylate kinase activity; integral to plasma membrane; membrane; membrane fraction; protein binding; signal transduction
BC002823	10758	chromosome 6 open reading frame 4	biological_process	cellular_component unknown; intracellular signaling cascade; molecular_function unknown
BC006314	1134	cholinergic receptor, nicotinic, alpha polypeptide 1 (muscle)	biological_process	acetylcholine receptor activity; extracellular ligand-gated ion channel activity; integral to membrane; ion channel activity; ion transport; muscle contraction; nicotinic acetylcholine-activated cation-selective channel activity; nicotinic acetylcholine-gated receptor-channel complex; signal transduction; synaptic transmission
BC007588	90864	SPRY domain-containing SOCS box protein SSB-3	biological_process	intracellular signaling cascade
BC011645	6236	Ras-related associated with diabetes	biological_process	GTP binding; calmodulin binding; small GTPase mediated signal transduction; small monomeric GTPase activity
BC014140	583	Bardet-Biedl syndrome 2	biological_process	biological_process unknown; cell-matrix adhesion; cellular_component unknown; integrin complex; molecular_function unknown; visual perception
BC014942	89941	ras homolog gene family, member T2	biological_process	GTP binding; calcium ion binding; small GTPase mediated signal transduction; small monomeric GTPase activity
BC015050	11339	Opa-interacting protein 5	biological_process	cell communication; cellular_component unknown; protein binding
BC016758	3059	hematopoietic cell-specific Lyn substrate 1	biological_process	DNA-directed RNA polymerase II, core complex; intracellular signaling cascade; regulation of transcription, DNA-dependent; transcription factor activity
BC017263	10960	lectin, mannose-binding 2	biological_process	Golgi apparatus; endoplasmic reticulum; heterophilic cell adhesion; integral to membrane; intracellular protein transport; protein transporter activity; sugar binding
BC019047	8742	tumor necrosis factor (ligand) superfamily, member 12	biological_process	angiogenesis; apoptosis; immune response; induction of apoptosis; integral to plasma membrane; signal transduction; tumor necrosis factor receptor binding
L12002	3676	integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)	biological_process	cell-matrix adhesion; integral to membrane; integrin complex; integrin-mediated signaling pathway; protein binding; receptor activity
U59748	50846	desert hedgehog homolog (Drosophila)	biological_process	cell-cell signaling; development; peptidase activity; proteolysis and peptidolysis
U66579	2843	G protein-coupled receptor 20	biological_process	G-protein coupled receptor protein signaling pathway; integral to plasma membrane; rhodopsin-like receptor activity
U68032	1235	chemokine (C-C motif) receptor 6	biological_process	C-C chemokine receptor activity; G-protein coupled receptor protein signaling pathway; antimicrobial humoral response (sensu Vertebrata); cell motility; cellular defense response; chemotaxis; cytosolic calcium ion concentration elevation; humoral immune response; integral to plasma membrane; receptor activity; rhodopsin-like receptor activity; signal transduction
U94905	8525	diacylglycerol kinase, zeta 104 kDa	biological_process	ATP binding; diacylglycerol binding; diacylglycerol kinase activity; intracellular signaling cascade; nucleus; protein kinase C activation; transferase activity
U96919	3631	inositol polyphosphate-4-phosphatase, type I, 107kDa	biological_process	signal transduction
X15002	3484	insulin-like growth factor binding protein 1	biological_process	cell growth and/or maintenance; extracellular space; insulin-like growth factor binding; regulation of cell growth; signal transduction
X52773	6256	retinoid X receptor, alpha	biological_process	nucleus; receptor activity; regulation of transcription, DNA-dependent; retinoid-X receptor activity; signal transduction; steroid binding; steroid hormone receptor activity; transcription coactivator activity; transcription factor activity; vitamin metabolism
X72886	7301	TYRO3 protein tyrosine kinase	biological_process	ATP binding; cell adhesion; integral to plasma membrane; protein amino acid phosphorylation; protein binding; receptor activity; receptor signaling protein tyrosine kinase activity; signal transduction; transferase activity; transmembrane receptor protein tyrosine kinase activity
X81892	10149	G protein-coupled receptor 64	biological_process	G-protein coupled receptor activity; integral to plasma membrane; membrane; neuropeptide signaling pathway; receptor activity; spermatogenesis
Z26317	1829	desmoglein 2	biological_process	calcium ion binding; cell adhesion; cytoskeleton; homophilic cell adhesion; integral to membrane; intercellular junction; protein binding
Z26491	1312	catechol-O-methyltransferase	biological_process	catechol O-methyltransferase activity; catecholamine metabolism; integral to membrane; magnesium ion binding; microsome; neurotransmitter catabolism; soluble fraction; transferase activity
Z83845	10454	mitogen-activated protein kinase kinase kinase 7 interacting protein 1	biological_process	activation of MAPKKK; catalytic activity; enzyme activator activity; protein binding; transforming growth factor beta receptor, cytoplasmic mediator activity
Z95636	3911	laminin, alpha 5	biological_process	basal lamina; cell adhesion; protein binding; structural molecule activity

Signal transduction.

Uniqid	Locuslink	Gene name	Classification	Locuslink classifications
AB002354	9842	adapter protein 162	biological_process	intracellular signaling cascade
AB037818	56995	tubby like protein 4	biological_process	cellular_component unknown; intracellular signaling cascade; regulation of transcription, DNA-dependent; transcription factor activity
AB044807	10207	InaD-like protein	biological_process	cellular_component unknown; intracellular signaling cascade; protein binding
AB052751	8313	axin 2 (conductin, axil)	biological_process	development; frizzled signaling pathway; intracellular; signal transducer activity; signal transduction
AB065846	259249	G protein-coupled receptor MRGX1	biological_process	G-protein coupled receptor protein signaling pathway; integral to membrane; receptor activity; rhodopsin-like receptor activity
AF034833	3679	integrin, alpha 7	biological_process	cell-matrix adhesion; cellular morphogenesis; homophilic cell adhesion; integrin complex; integrin-mediated signaling pathway; muscle development; protein binding; receptor activity
AF053356	2056	erythropoietin	biological_process	cell-cell signaling; circulation; development; erythropoietin receptor binding; extracellular space; hormone activity; response to stress; signal transduction
AF053356	2783	guanine nucleotide binding protein (G protein), beta polypeptide 2	biological_process	G-protein coupled receptor protein signaling pathway; heterotrimeric G-protein GTPase activity; heterotrimeric G-protein complex; signal transducer activity; signal transduction
AF061943	51677	prostate derived STE20-like kinase PSK	biological_process	ATP binding; actin cytoskeleton organization and biogenesis; activation of MAPKK; apoptosis; cell migration; cytoplasmic vesicle; focal adhesion formation; positive regulation of JNK cascade; protein amino acid phosphorylation; protein serine/threonine kinase activity; protein-membrane targeting; regulation of cell growth; regulation of cell shape; response to stress; transferase activity
AF120324	26230	T-cell lymphoma invasion and metastasis 2	biological_process	guanyl-nucleotide exchange factor activity; intracellular signaling cascade; protein binding; receptor signaling protein activity
AF130420	9372	MAD, mothers against decapentaplegic homolog (Drosophila) interacting protein, receptor activation anchor	biological_process	SMAD protein heteromerization; SMAD protein nuclear translocation; cytoplasm; early endosome; endocytosis; protein binding; receptor activity; serine-type peptidase activity; transforming growth factor beta receptor complex assembly; zinc ion binding
AF141901	22941	SH3 and multiple ankyrin repeat domains 2	biological_process	GKAP/Homer scaffold activity; cellular_component unknown; intracellular signaling cascade; protein binding
AF172264	23043	Traf2 and NCK interacting kinase	biological_process	ATP binding; protein amino acid phosphorylation; protein kinase cascade; protein serine/threonine kinase activity; regulation of translation; response to stress; small GTPase regulatory/interacting protein activity; transferase activity
AF222689	3276	HMT1 hnRNP methyltransferase-like 2 (S. cerevisiae)	biological_process	N-methyltransferase activity; S-adenosylmethionine-dependent methyltransferase activity; cell surface receptor linked signal transduction; cytoplasm; defense response; nucleus; protein amino acid methylation; transferase activity
AF227129	50834	taste receptor, type 2, member 1	biological_process	G-protein coupled receptor activity; G-protein coupled receptor protein signaling pathway; biological_process unknown; chemosensory behavior; integral to membrane; receptor activity; taste receptor activity
AF236083	10886	G protein-coupled receptor 74	biological_process	G-protein coupled receptor activity; G-protein coupled receptor protein signaling pathway; cell growth and/or maintenance; detection of abiotic stimulus; integral to plasma membrane; neuropeptide receptor activity; rhodopsin-like receptor activity
AF237775	2872	MAP kinase-interacting serine/threonine kinase 2	biological_process	ATP binding; protein amino acid phosphorylation; protein kinase cascade; protein serine/threonine kinase activity; regulation of protein biosynthesis; regulation of translation; response to stress; transferase activity
AF258564	7410	vav 2 oncogene	biological_process	diacylglycerol binding; guanyl-nucleotide exchange factor activity; intracellular signaling cascade
AF276423	55914	erbb2 interacting protein	biological_process	Neu/ErbB-2 receptor binding; basal plasma membrane; basal protein localization; cell adhesion; cell cycle; cell growth; cytoplasm; epidermal growth factor receptor signaling pathway; establishment and/or maintenance of epithelial cell polarity; hemidesmosome; integrin binding; integrin-mediated signaling pathway; intermediate filament cytoskeleton organization and biogenesis; nucleus; protein binding; structural constituent of cytoskeleton
AF420474	5597	mitogen-activated protein kinase 6	biological_process	ATP binding; MAP kinase activity; cell cycle; protein amino acid phosphorylation; protein serine/threonine kinase activity; signal transduction; transferase activity
AK000814	8681	phospholipase A2, group IVB (cytosolic)	biological_process	arachidonic acid metabolism; calcium ion binding; calcium-dependent phospholipase A2 activity; calcium-dependent phospholipid binding; calcium-mediated signaling; cytosol; extracellular; glycerophospholipid catabolism; inflammatory response; parturition; phospholipase activity
AK027377	59352	leucine-rich repeat-containing G protein-coupled receptor 6	biological_process	G-protein coupled receptor protein signaling pathway; integral to membrane; protein-hormone receptor activity
AK092864	64759	tensin-like SH2 domain-containing 1	biological_process	intracellular signaling cascade; phosphoprotein phosphatase activity; protein amino acid dephosphorylation
AY046538	8601	regulator of G-protein signalling 20	biological_process	GTPase activator activity; membrane; protein binding; regulation of G-protein coupled receptor protein signaling pathway; signal transducer activity; signal transduction
BC000043	379	ADP-ribosylation factor 4-like	biological_process	ARF small monomeric GTPase activity; GTP binding; nucleus; protein secretion; small GTPase mediated signal transduction
BC000493	1819	developmentally regulated GTP binding protein 2	biological_process	GTP binding; cell growth and/or maintenance; signal transduction
BC002392	4354	membrane protein, palmitoylated 1, 55 kDa	biological_process	guanylate kinase activity; integral to plasma membrane; membrane; membrane fraction; protein binding; signal transduction
BC002823	10758	chromosome 6 open reading frame 4	biological_process	cellular_component unknown; intracellular signaling cascade; molecular_function unknown
BC006314	1134	cholinergic receptor, nicotinic, alpha polypeptide 1 (muscle)	biological_process	acetylcholine receptor activity; extracellular ligand-gated ion channel activity; integral to membrane; ion channel activity; ion transport; muscle contraction; nicotinic acetylcholine-activated cation-selective channel activity; nicotinic acetylcholine-gated receptor-channel complex; signal transduction; synaptic transmission
BC007588	90864	SPRY domain-containing SOCS box protein SSB-3	biological_process	intracellular signaling cascade
BC011645	6236	Ras-related associated with diabetes	biological_process	GTP binding; calmodulin binding; small GTPase mediated signal transduction; small monomeric GTPase activity
BC014942	89941	ras homolog gene family, member T2	biological_process	GTP binding; calcium ion binding; small GTPase mediated signal transduction; small monomeric GTPase activity
BC016758	3059	hematopoietic cell-specific Lyn substrate 1	biological_process	DNA-directed RNA polymerase II, core complex; intracellular signaling cascade; regulation of transcription, DNA-dependent; transcription factor activity
BC019047	8742	tumor necrosis factor (ligand) superfamily, member 12	biological_process	angiogenesis; apoptosis; immune response; induction of apoptosis; integral to plasma membrane; signal transduction; tumor necrosis factor receptor binding
L12002	3676	integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)	biological_process	cell-matrix adhesion; integral to membrane; integrin complex; integrin-mediated signaling pathway; protein binding; receptor activity
U66579	2843	G protein-coupled receptor 20	biological_process	G-protein coupled receptor protein signaling pathway; integral to plasma membrane; rhodopsin-like receptor activity
U68032	1235	chemokine (C-C motif) receptor 6	biological_process	C-C chemokine receptor activity; G-protein coupled receptor protein signaling pathway; antimicrobial humoral response (sensu Vertebrata); cell motility; cellular defense response; chemotaxis; cytosolic calcium ion concentration elevation; humoral immune response; integral to plasma membrane; receptor activity; rhodopsin-like receptor activity; signal transduction
U94905	8525	diacylglycerol kinase, zeta 104 kDa	biological_process	ATP binding; diacylglycerol binding; diacylglycerol kinase activity; intracellular signaling cascade; nucleus; protein kinase C activation; transferase activity
U96919	3631	inositol polyphosphate-4-phosphatase, type I, 107 kDa	biological_process	signal transduction
X15002	3484	insulin-like growth factor binding protein 1	biological_process	cell growth and/or maintenance; extracellular space; insulin-like growth factor binding; regulation of cell growth; signal transduction
X52773	6256	retinoid X receptor, alpha	biological_process	nucleus; receptor activity; regulation of transcription, DNA-dependent; retinoid-X receptor activity; signal transduction; steroid binding; steroid hormone receptor activity; transcription coactivator activity; transcription factor activity; vitamin metabolism
X72886	7301	TYRO3 protein tyrosine kinase	biological_process	ATP binding; cell adhesion; integral to plasma membrane; protein amino acid phosphorylation; protein binding; receptor activity; receptor signaling protein tyrosine kinase activity; signal transduction; transferase activity; transmembrane receptor protein tyrosine kinase activity
X81892	10149	G protein-coupled receptor 64	biological_process	G-protein coupled receptor activity; integral to plasma membrane; membrane; neuropeptide signaling pathway; receptor activity; spermatogenesis
Z83845	10454	mitogen-activated protein kinase kinase kinase 7 interacting protein 1	biological_process	activation of MAPKKK; catalytic activity; enzyme activator activity; protein binding; transforming growth factor beta receptor, cytoplasmic mediator activity

Receptor signaling protein activity.

Uniqid	Locuslink	Gene name	Classification	Locuslink classifications
AB002309	9472	A kinase (PRKA) anchor protein 6	molecular_function	nuclear membrane; protein kinase A anchoring activity; protein targeting; sarcoplasmic reticulum
AF120324	26230	T-cell lymphoma invasion and metastasis 2	molecular_function	guanyl-nucleotide exchange factor activity; intracellular signaling cascade; protein binding; receptor signaling protein activity
AF141901	22941	SH3 and multiple ankyrin repeat domains 2	molecular_function	GKAP/Homer scaffold activity; cellular_component unknown; intracellular signaling cascade; protein binding
AF420474	5597	mitogen-activated protein kinase 6	molecular_function	ATP binding; MAP kinase activity; cell cycle; protein amino acid phosphorylation; protein serine/threonine kinase activity; signal transduction; transferase activity
X72886	7301	TYRO3 protein tyrosine kinase	molecular_function	ATP binding; cell adhesion; integral to plasma membrane; protein amino acid phosphorylation; protein binding; receptor activity; receptor signaling protein tyrosine kinase activity; signal transduction; transferase activity; transmembrane receptor protein tyrosine kinase activity
Z83845	10454	mitogen-activated protein kinase kinase kinase 7 interacting protein 1	molecular_function	activation of MAPKKK; catalytic activity; enzyme activator activity; protein binding; transforming growth factor beta receptor, cytoplasmic mediator activity

Organismal movement.

Uniqid	Locuslink	Gene name	Classification	Locuslink classifications
AF336797	3782	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3	biological_process	calcium-activated potassium channel activity; calmodulin binding; integral to membrane; ion channel activity; ion transport; membrane fraction; neurogenesis; potassium ion transport; small conductance calcium-activated potassium channel activity; synaptic transmission; voltage-gated potassium channel complex
AJ295237	57053	cholinergic receptor, nicotinic, alpha polypeptide 10	biological_process	extracellular ligand-gated ion channel activity; integral to membrane; ion channel activity; ion transport; neurotransmitter receptor activity; nicotinic acetylcholine-activated cation-selective channel activity; receptor binding; regulation of cell proliferation; synaptic transmission; synaptic transmission, cholinergic
AK027243	582	Bardet-Biedl syndrome 1	biological_process	visual perception
BC006314	1134	cholinergic receptor, nicotinic, alpha polypeptide 1 (muscle)	biological_process	acetylcholine receptor activity; extracellular ligand-gated ion channel activity; integral to membrane; ion channel activity; ion transport; muscle contraction; nicotinic acetylcholine-activated cation-selective channel activity; nicotinic acetylcholine-gated receptor-channel complex; signal transduction; synaptic transmission
BC014140	583	Bardet-Biedl syndrome 2	biological_process	biological_process unknown; cell-matrix adhesion; cellular_component unknown; integrin complex; molecular_function unknown; visual perception
Z26491	1312	catechol-O-methyltransferase	biological_process	catechol O-methyltransferase activity; catecholamine metabolism; integral to membrane; magnesium ion binding; microsome; neurotransmitter catabolism; soluble fraction; transferase activity

Detection of external stimulus.

Uniqid	Locuslink	Gene name	Classification	Locuslink classifications
AF107403	9381	otoferlin	biological_process	biological_process unknown; cellular_component unknown; integral to membrane; molecular_function unknown; perception of sound
AF236083	10886	G protein-coupled receptor 74	biological_process	G-protein coupled receptor activity; G-protein coupled receptor protein signaling pathway; cell growth and/or maintenance; detection of abiotic stimulus; integral to plasma membrane; neuropeptide receptor activity; rhodopsin-like receptor activity
AK027243	582	Bardet-Biedl syndrome 1	biological_process	visual perception
BC012126	23562	claudin 14	biological_process	integral to membrane; perception of sound; protein complex assembly; structural molecule activity; tight junction
BC014140	583	Bardet-Biedl syndrome 2	biological_process	biological_process unknown; cell-matrix adhesion; cellular_component unknown; integrin complex; molecular_function unknown; visual perception
M31013	4627	myosin, heavy polypeptide 9, non-muscle	biological_process	ATP binding; actin binding; calmodulin binding; cellular morphogenesis; motor activity; myosin; non-muscle myosin; perception of sound

Regulation of cell cycle.

Uniqid	Locuslink	Gene name	Classification	Locuslink classifications
AB000381	2765	GPI anchored molecule like protein	biological_process	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; apoptosis; extrinsic to membrane; negative regulation of cell proliferation; plasma membrane; regulation of cell cycle
AK074614	3481	insulin-like growth factor 2 (somatomedin A)	biological_process	cell proliferation; development; extracellular; growth factor activity; growth pattern; hormone activity; imprinting; insulin receptor signaling pathway; insulin-like growth factor receptor binding; physiological process; regulation of cell cycle; skeletal development
Y13444	4335	MAX binding protein	biological_process	cell proliferation; development; negative regulation of cell proliferation; nucleus; regulation of cell cycle; regulation of transcription, DNA-dependent; transcription coactivator activity; transcription corepressor activity; transcription factor activity; transcription from Pol II promoter

Metabolism.

Uniqid	Locuslink	Gene name	Classification	Locuslink Classifications
AB014564	23277	KIAA0664 protein	biological_process	protein biosynthesis; translation initiation factor activity
AK011657	20383	splicing factor, arginine/serine-rich 3 (SRp20)	biological_process	RNA binding; mRNA splice site selection; spliceosome complex
AK074614	3481	insulin-like growth factor 2 (somatomedin A)	biological_process	cell proliferation; development; extracellular; growth factor activity; growth pattern; hormone activity; imprinting; insulin receptor signaling pathway; insulin-like growth factor receptor binding; physiological process; regulation of cell cycle; skeletal development
AL390164	54815	p66 alpha	biological_process	DNA methylation; NuRD complex; negative regulation of transcription, DNA-dependent; nucleus; protein binding, bridging; transcription factor activity; transcriptional repressor activity
BC013964	252969	nei like 2 (E. coli)	biological_process	DNA repair
S72422	1743	dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex)	biological_process	acetyl-CoA biosynthesis; acyltransferase activity; alpha-ketoglutarate dehydrogenase complex (sensu Eukarya); dihydrolipoyllysine-residue succinyltransferase activity; energy pathways; metabolism; mitochondrion; oxoglutarate dehydrogenase complex; transferase activity; tricarboxylic acid cycle
U14550	10610	sialyltransferase 7 ((alpha-N- acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl galactosaminide alpha-2,6-sialyltransferase) B	biological_process	Golgi apparatus; integral to membrane; protein amino acid glycosylation; sialyltransferase activity; transferase activity, transferring glycosyl groups
X85019	2590	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 2 (GalNAc-T2)	biological_process	O-linked glycosylation; polypeptide N-acetylgalactosaminyltransferase activity; transferase activity
Y13444	4335	MAX binding protein	biological_process	cell proliferation; development; negative regulation of cell proliferation; nucleus; regulation of cell cycle; regulation of transcription, DNA-dependent; transcription coactivator activity; transcription corepressor activity; transcription factor activity; transcription from Pol II promoter

Biosynthesis.

Uniqid	Locuslink	Gene name	Classification	Locuslink Classifications
AB014564	23277	KIAA0664 protein	biological_process	protein biosynthesis; translation initiation factor activity
S72422	1743	dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex)	biological_process	acetyl-CoA biosynthesis; acyltransferase activity; alpha-ketoglutarate dehydrogenase complex (sensu Eukarya); dihydrolipoyllysine-residue succinyltransferase activity; energy pathways; metabolism; mitochondrion; oxoglutarate dehydrogenase complex; transferase activity; tricarboxylic acid cycle
U14550	10610	sialyltransferase 7 ((alpha-N- acetylneuraminyl-2,3-beta- galactosyl-1,3)-N-acetyl galactosaminide alpha-2,6-sialyltransferase) B	biological_process	Golgi apparatus; integral to membrane; protein amino acid glycosylation; sialyltransferase activity; transferase activity, transferring glycosyl groups
X85019	2590	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 2 (GalNAc-T2)	biological_process	O-linked glycosylation; polypeptide N-acetylgalactosaminyltransferase activity; transferase activity

Protein biosynthesis.

Uniqid	Locuslink	Gene name	Classification	Locuslink Classifications
AB014564	23277	KIAA0664 protein	biological_process	protein biosynthesis; translation initiation factor activity
U14550	10610	sialyltransferase 7 ((alpha-N- acetylneuraminyl-2,3-beta- galactosyl-1,3)-N-acetyl galactosaminide alpha-2,6-sialyltransferase) B	biological_process	Golgi apparatus; integral to membrane; protein amino acid glycosylation; sialyltransferase activity; transferase activity, transferring glycosyl groups
X85019	2590	UDP-N-acetyl-alpha-D-galactosamine polypeptide N-acetylgalactosaminyltransferase 2 (GalNAc-T2)	biological_process	O-linked glycosylation; polypeptide N-acetylgalactosaminyltransferase activity; transferase activity

Cell cycle.

Uniqid	Locuslink	Gene name	Classification	Locuslink classifications
AB000381	2765	GPI anchored molecule like protein	biological_process	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; apoptosis; extrinsic to membrane; negative regulation of cell proliferation; plasma membrane; regulation of cell cycle
AK074614	3481	insulin-like growth factor 2 (somatomedin A)	biological_process	cell proliferation; development; extracellular; growth factor activity; growth pattern; hormone activity; imprinting; insulin receptor signaling pathway; insulin-like growth factor receptor binding; physiological process; regulation of cell cycle; skeletal development
Y13444	4335	MAX binding protein	biological_process	cell proliferation; development; negative regulation of cell proliferation; nucleus; regulation of cell cycle; regulation of transcription, DNA-dependent; transcription coactivator activity; transcription corepressor activity; transcription factor activity; transcription from Pol II promoter

Nucleobase, nucleoside, nucleotide and nucleic acid metabolism.

Uniqid	Locuslink	Gene name	Classification	Locuslink classifications
AK011657	20383	splicing factor, arginine/serine-rich 3 (SRp20)	biological_process	RNA binding; mRNA splice site selection; spliceosome complex
AK074614	3481	insulin-like growth factor 2 (somatomedin A)	biological_process	cell proliferation; development; extracellular; growth factor activity; growth pattern; hormone activity; imprinting; insulin receptor signaling pathway; insulin-like growth factor receptor binding; physiological process; regulation of cell cycle; skeletal development
AL390164	54815	p66 alpha	biological_process	DNA methylation; NuRD complex; negative regulation of transcription, DNA-dependent; nucleus; protein binding, bridging; transcription factor activity; transcriptional repressor activity
BC013964	252969	nei like 2 (E. coli)	biological_process	DNA repair
Y13444	4335	MAX binding protein	biological_process	cell proliferation; development; negative regulation of cell proliferation; nucleus; regulation of cell cycle; regulation of transcription, DNA-dependent; transcription coactivator activity; transcription corepressor activity; transcription factor activity; transcription from Pol II promoter

Macromolecule biosynthesis.

Uniqid	Locuslink	Gene name	Classification	Locuslink classifications
AB014564	23277	KIAA0664 protein	biological_process	protein biosynthesis; translation initiation factor activity
U14550	10610	sialyltransferase 7 ((alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl galactosaminide alpha -2, 6-sialyltransferase) B	biological_process	Golgi apparatus; integral to membrane; protein amino acid glycosylation; sialyltransferase activity; transferase activity, transferring glycosyl groups
X85019	2590	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 2 (GalNAc-T2)	biological_process	O-linked glycosylation; polypeptide N-acetylgalactosaminyltransferase activity; transferase activity

Metal ion binding.

Uniqid	Locuslink	Gene name	Classification	Locuslink classifications
AB024742	9331	UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 6	molecular_function	Golgi apparatus; carbohydrate metabolism; galactosyltransferase activity; integral to membrane; magnesium ion binding; manganese ion binding; transferase activity, transferring glycosyl groups
AC004668	30013	S100 calcium binding protein A11 pseudogene	molecular_function	calcium ion binding
AD001527	5438	polymerase (RNA) II (DNA directed) polypeptide I, 14.5 kDa	molecular_function	DNA-directed RNA polymerase II, core complex; DNA-directed RNA polymerase activity; RNA elongation; nucleus; regulation of transcription, DNA-dependent; transcription; transcription factor activity; transcription from Pol II promoter; transferase activity; zinc ion binding
AD001527	826	calpain, small subunit 1	molecular_function	calcium ion binding; calpain activity; positive regulation of cell proliferation
BC012822	308	annexin A5	molecular_function	blood coagulation; calcium ion binding; calcium-dependent phospholipid binding; negative regulation of coagulation; phospholipase inhibitor activity
BC017054	10797	methylene tetrahydrofolate dehydrogenase (NAD + dependent), methenyltetrahydrofolate cyclohydrolase	molecular_function	electron transporter activity; folic acid and derivative biosynthesis; hydrolase activity; magnesium ion binding; methenyltetrahydrofolate cyclohydrolase activity; methylenetetrahydrofolate dehydrogenase (NAD+) activity; mitochondrion; one-carbon compound metabolism; oxidoreductase activity
D49387	22949	leukotriene B4 12-hydroxydehydrogenase	molecular_function	alcohol dehydrogenase activity, zinc-dependent; cytoplasm; leukotriene metabolism; oxidoreductase activity; zinc ion binding
Z29064	2060	epidermal growth factor receptor pathway substrate 15	molecular_function	calcium ion binding

Cytoplasm.

Uniqid	Locuslink	Gene name	Classification	Locuslink classifications
AB024742	9331	UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 6	cellular_component	Golgi apparatus; carbohydrate metabolism; galactosyltransferase activity; integral to membrane; magnesium ion binding; manganese ion binding; transferase activity, transferring glycosyl groups
AF010472	5066	peptidylglycine alpha-amidating monooxygenase	cellular_component	peptide amidation; peptidylglycine monooxygenase activity; secretory granule
AF049895	1666	2,4-dienoyl CoA reductase 1, mitochondrial	cellular_component	2,4-dienoyl-CoA reductase (NADPH) activity; metabolism; mitochondrion; oxidoreductase activity
AF281070	1981	eukaryotic translation initiation factor 4 gamma, 1	cellular_component	RNA binding; eukaryotic translation initiation factor 4F complex; regulation of protein biosynthesis; regulation of translational initiation; translation initiation factor activity
AL050179	7168	tropomyosin 1 (alpha)	cellular_component	actin binding; biological_process unknown; cellular_component unknown; cytoskeleton; molecular_function unknown; muscle development; muscle thin filament tropomyosin; regulation of heart rate; regulation of muscle contraction; structural constituent of cytoskeleton; structural constituent of muscle
AY007112	55737	vacuolar protein sorting 35 (yeast)	cellular_component	cytosol; intracellular protein transport; protein binding; protein transporter activity; retrograde transport, endosome to Golgi
BC000747	23404	homolog of Yeast RRP4 (ribosomal RNA processing 4), 3′-5′-exoribonuclease	cellular_component	3′-5′-exoribonuclease activity; 7S RNA binding; cytoplasm; exonuclease activity; exosome (RNase complex); hydrolase activity; nucleus; rRNA processing
BC005923	4257	microsomal glutathione S-transferase 1	cellular_component	glutathione transferase activity; membrane; microsome; mitochondrion; transferase activity
BC009772	51601	lipoyltransferase 1	cellular_component	ligase activity; lipid metabolism; mitochondrion; protein modification
BC012333	6309	sterol-C5-desaturase (ERG3 delta-5-desaturase homolog, fungal)-like	cellular_component	C-5 sterol desaturase activity; endoplasmic reticulum; integral to membrane; lathosterol oxidase activity; lipid metabolism; oxidoreductase activity; sterol biosynthesis
BC017054	10797	methylene tetrahydrofolate dehydrogenase (NAD+ dependent), methenyltetrahydrofolate cyclohydrolase	cellular_component	electron transporter activity; folic acid and derivative biosynthesis; hydrolase activity; magnesium ion binding; methenyltetrahydrofolate cyclohydrolase activity; methylenetetrahydrofolate dehydrogenase (NAD+) activity; mitochondrion; one-carbon compound metabolism; oxidoreductase activity
BC017883	26589	mitochondrial ribosomal protein L46	cellular_component	mitochondrion; structural constituent of ribosome
BC018049	5217	profilin 2	cellular_component	actin binding; actin cytoskeleton; actin cytoskeleton organization and biogenesis; cytoskeleton organization and biogenesis; phosphatidylinositol-4,5-bisphosphate binding; regulation of actin polymerization and/or depolymerization
D49387	22949	leukotriene B4 12-hydroxydehydrogenase	cellular_component	alcohol dehydrogenase activity, zinc-dependent; cytoplasm; leukotriene metabolism; oxidoreductase activity; zinc ion binding
L40383	9320	thyroid hormone receptor interactor 12	cellular_component	cellular_component unknown; cytosol; intracellular; ligase activity; protein ubiquitination; thyroid hormone receptor binding; ubiquitin-protein ligase activity
M19735	3074	hexosaminidase B (beta polypeptide)	cellular_component	beta-N-acetylhexosaminidase activity; carbohydrate metabolism; glycosphingolipid metabolism; hydrolase activity, acting on glycosyl bonds; lysosome

Oxidoreductase activity.

Uniqid	Locuslink	Gene name	Classification	Locuslink classifications
AF010472	5066	peptidylglycine alpha-amidating monooxygenase	molecular_function	peptide amidation; peptidylglycine monooxygenase activity; secretory granule
AF049895	1666	2,4-dienoyl CoA reductase 1, mitochondrial	molecular_function	2,4-dienoyl-CoA reductase (NADPH) activity; metabolism; mitochondrion; oxidoreductase activity
BC012333	6309	sterol-C5-desaturase (ERG3 delta-5-desaturase homolog, fungal)-like	molecular_function	C-5 sterol desaturase activity; endoplasmic reticulum; integral to membrane; lathosterol oxidase activity; lipid metabolism; oxidoreductase activity; sterol biosynthesis
BC017054	10797	methylene tetrahydrofolate dehydrogenase (NAD+ dependent), methenyltetrahydrofolate cyclohydrolase	molecular_function	electron transporter activity; folic acid and derivative biosynthesis; hydrolase activity; magnesium ion binding; methenyltetrahydrofolate cyclohydrolase activity; methylenetetrahydrofolate dehydrogenase (NAD+) activity; mitochondrion; one-carbon compound metabolism; oxidoreductase activity
D49387	22949	leukotriene B4 12-hydroxydehydrogenase	molecular_function	alcohol dehydrogenase activity, zinc-dependent; cytoplasm; leukotriene metabolism; oxidoreductase activity; zinc ion binding

Oxidoreductase activity.

Uniqid	Locuslink	Gene name	Classification	Locuslink classifications
AF010472	5066	peptidylglycine alpha-amidating monooxygenase	molecular_function	peptide amidation; peptidylglycine monooxygenase activity; secretory granule
AF049895	1666	2,4-dienoyl CoA reductase 1, mitochondrial	molecular_function	2,4-dienoyl-CoA reductase (NADPH) activity; metabolism; mitochondrion; oxidoreductase activity
BC012333	6309	sterol-C5-desaturase (ERG3 delta-5-desaturase homolog, fungal)-like	molecular_function	C-5 sterol desaturase activity; endoplasmic reticulum; integral to membrane; lathosterol oxidase activity; lipid metabolism; oxidoreductase activity; sterol biosynthesis
BC017054	10797	methylene tetrahydrofolate dehydrogenase (NAD + dependent), methenyltetrahydrofolate cyclohydrolase	molecular_function	electron transporter activity; folic acid and derivative biosynthesis; hydrolase activity; magnesium ion binding; methenyltetrahydrofolate cyclohydrolase activity; methylenetetrahydrofolate dehydrogenase (NAD+) activity; mitochondrion; one-carbon compound metabolism; oxidoreductase activity
D49387	22949	leukotriene B4 12-hydroxydehydrogenase	molecular_function	alcohol dehydrogenase activity, zinc-dependent; cytoplasm; leukotriene metabolism; oxidoreductase activity; zinc ion binding

Mitochondrion.

Uniqid	Locuslink	Gene name	Classification	Locuslink classifications
AF049895	1666	2,4-dienoyl CoA reductase 1, mitochondrial	cellular_component	2,4-dienoyl-CoA reductase (NADPH) activity; metabolism; mitochondrion; oxidoreductase activity
BC005923	4257	microsomal glutathione S-transferase 1	cellular_component	glutathione transferase activity; membrane; microsome; mitochondrion; transferase activity
BC009772	51601	lipoyltransferase 1	cellular_component	ligase activity; lipid metabolism; mitochondrion; protein modification
BC017054	10797	methylene tetrahydrofolate dehydrogenase (NAD+ dependent), methenyltetrahydrofolate cyclohydrolase	cellular_component	electron transporter activity; folic acid and derivative biosynthesis; hydrolase activity; magnesium ion binding; methenyltetrahydrofolate cyclohydrolase activity; methylenetetrahydrofolate dehydrogenase (NAD+) activity; mitochondrion; one-carbon compound metabolism; oxidoreductase activity
BC017883	26589	mitochondrial ribosomal protein L46	cellular_component	mitochondrion; structural constituent of ribosome

Calcium ion binding.

Uniqid	Locuslink	Gene name	Classification	Locuslink classifications
AC004668	30013	S100 calcium binding protein A11 pseudogene	molecular_function	calcium ion binding
AD001527	826	calpain, small subunit 1	molecular_function	calcium ion binding; calpain activity; positive regulation of cell proliferation
BC012822	308	annexin A5	molecular_function	blood coagulation; calcium ion binding; calcium-dependent phospholipid binding; negative regulation of coagulation; phospholipase inhibitor activity
Z29064	2060	epidermal growth factor receptor pathway substrate 15	molecular_function	calcium ion binding

Lipid metabolism.

Uniqid	Locuslink	Gene name	Classification	Locuslink classifications
BC009772	51601	lipoyltransferase 1	biological_process	ligase activity; lipid metabolism; mitochondrion; protein modification
BC012333	6309	sterol-C5-desaturase (ERG3 delta-5-desaturase homolog, fungal)-like	biological_process	C-5 sterol desaturase activity; endoplasmic reticulum; integral to membrane; lathosterol oxidase activity; lipid metabolism; oxidoreductase activity; sterol biosynthesis
D49387	22949	leukotriene B4 12-hydroxydehydrogenase	biological_process	alcohol dehydrogenase activity, zinc-dependent; cytoplasm; leukotriene metabolism; oxidoreductase activity; zinc ion binding
M19735	3074	hexosaminidase B (beta polypeptide)	biological_process	beta-N-acetylhexosaminidase activity; carbohydrate metabolism; glycosphingolipid metabolism; hydrolase activity, acting on glycosyl bonds; lysosome

Response to abiotic stimulus.

Uniqid	Locuslink	Gene name	Classification	Locuslink classifications
AF107403	9381	otoferlin	biological_process	biological_process unknown; cellular_component unknown; integral to membrane; molecular_function unknown; perception of sound
AF385628	3576	interleukin 8	biological_process	G-protein coupled receptor protein signaling pathway; angiogenesis; calcium-mediated signaling; cell cycle arrest; cell motility; cell-cell signaling; chemokine activity; chemotaxis; extracellular space; immune response; induction of positive chemotaxis; interleukin-8 receptor binding; intracellular signaling cascade; negative regulation of cell proliferation; neutrophil activation; neutrophil chemotaxis; regulation of cell adhesion; regulation of retroviral genome replication; soluble fraction
BC021093	84641	hypothetical protein FLJ14753	biological_process	integral to membrane; tetracycline transport; tetracycline:hydrogen antiporter activity

Hydrolase activity.

Uniqid	Locuslink	Gene name	Classification	Locuslink classifications
AL117503	7398	ubiquitin specific protease 1	molecular_function	cysteine-type endopeptidase activity; hydrolase activity; ubiquitin thiolesterase activity; ubiquitin-dependent protein catabolism; ubiquitin-specific protease activity
BC000346	8446	dual specificity phosphatase 11 (RNA/RNP complex 1-interacting)	molecular_function	RNA binding; RNA processing; hydrolase activity; nucleus; protein amino acid dephosphorylation; protein-tyrosine-phosphatase activity
BC015505	11325	DEAD (Asp-Glu-Ala-Asp) box polypeptide 42	molecular_function	ATP binding; ATP-dependent helicase activity; hydrolase activity; nucleic acid binding
BC022445	5685	proteasome (prosome, macropain) subunit, alpha type, 4	molecular_function	endopeptidase activity; proteasome core complex (sensu Eukarya); ubiquitin-dependent protein catabolism
BC022865	539	ATP synthase, H + transporting, mitochondrial F1 complex, O subunit (oligomycin sensitivity conferring protein)	molecular_function	ATP biosynthesis; hydrogen ion transporter activity; hydrolase activity; membrane fraction; mitochondrion; proton transport; proton-transporting ATP synthase complex (sensu Eukarya); transporter activity
J03004	2771	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	molecular_function	G-protein coupled receptor protein signaling pathway; GTP binding; heterotrimeric G-protein GTPase activity; negative regulation of adenylate cyclase activity; response to nutrients; signal transducer activity; signal transduction

Cell fraction.

Uniqid	Locuslink	Gene name	Classification	Locuslink classifications
AF059274	10675	chondroitin sulfate proteoglycan 5 (neuroglycan C)	cellular_component	Golgi apparatus; Golgi vesicle membrane; growth factor activity; integral to plasma membrane; intracellular transport; membrane fraction; neurogenesis; protein binding
BC022865	539	ATP synthase, H + transporting, mitochondrial F1 complex, O subunit (oligomycin sensitivity conferring protein)	cellular_component	ATP biosynthesis; hydrogen ion transporter activity; hydrolase activity; membrane fraction; mitochondrion; proton transport; proton-transporting ATP synthase complex (sensu Eukarya); transporter activity
Y07909	2012	epithelial membrane protein 1	cellular_component	cell death; cell growth; cell proliferation; development; epidermal differentiation; integral to membrane; membrane fraction

Cytosol.

Uniqid	Locuslink	Gene name	Classification	Locuslink classifications
AB055804	5204	prefoldin 5	cellular_component	chaperone activity; nucleus; prefoldin complex; protein folding; regulation of transcription, DNA-dependent; transcription corepressor activity
AC004263	6175	ribosomal protein, large, P0	cellular_component	RNA binding; cytosolic large ribosomal subunit (sensu Eukarya); intracellular; protein biosynthesis; ribosome; structural constituent of ribosome; translational elongation
AL050366	8473	O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)	cellular_component	O-linked glycosylation; acetylglucosaminyltransferase activity; cytosol; nucleus; protein binding; response to nutrients; signal transduction; transferase activity, transferring glycosyl groups
D10755	29673	proteasome (prosome, macropain) subunit, alpha type 6	cellular_component	RNA binding; cytosol; endopeptidase activity; hydrolase activity; peptidase activity; proteasome core complex (sensu Eukarya); ubiquitin-dependent protein catabolism
X06423	65136	ribosomal protein S8	cellular_component	RNA binding; cytosolic ribosome (sensu Eukarya); cytosolic small ribosomal subunit (sensu Eukarya); intracellular; protein biosynthesis; ribonucleoprotein complex; ribosome; ribosome biogenesis; structural constituent of ribosome
X80699	19941	ribosomal protein L26	cellular_component	RNA binding; cytosolic large ribosomal subunit (sensu Eukarya); cytosolic ribosome (sensu Eukarya); intracellular; protein biosynthesis; ribosome; ribosome biogenesis; structural constituent of ribosome
X82202	81767	ribosomal protein L19	cellular_component	RNA binding; cytosolic large ribosomal subunit (sensu Eukarya); intracellular; protein biosynthesis; ribosome; structural constituent of ribosome

Large ribosomal subunit.

Uniqid	Locuslink	Gene name	Classification	Locuslink classifications
AC004263	6175	ribosomal protein, large, P0	cellular_component	RNA binding; cytosolic large ribosomal subunit (sensu Eukarya); intracellular; protein biosynthesis; ribosome; structural constituent of ribosome; translational elongation
AF083248	51121	ribosomal protein L26-like 1	cellular_component	intracellular; large ribosomal subunit; protein biosynthesis; structural constituent of ribosome
X80699	19941	ribosomal protein L26	cellular_component	RNA binding; cytosolic large ribosomal subunit (sensu Eukarya); cytosolic ribosome (sensu Eukarya); intracellular; protein biosynthesis; ribosome; ribosome biogenesis; structural constituent of ribosome
X82202	81767	ribosomal protein L19	cellular_component	RNA binding; cytosolic large ribosomal subunit (sensu Eukarya); intracellular; protein biosynthesis; ribosome; structural constituent of ribosome

Cytosolic ribosome (sensu Eukarya).

Uniqid	Locuslink	Gene name	Classification	Locuslink classifications
AC004263	6175	ribosomal protein, large, P0	cellular_component	RNA binding; cytosolic large ribosomal subunit (sensu Eukarya); intracellular; protein biosynthesis; ribosome; structural constituent of ribosome; translational elongation
X06423	65136	ribosomal protein S8	cellular_component	RNA binding; cytosolic ribosome (sensu Eukarya); cytosolic small ribosomal subunit (sensu Eukarya); intracellular; protein biosynthesis; ribonucleoprotein complex; ribosome; ribosome biogenesis; structural constituent of ribosome
X80699	19941	ribosomal protein L26	cellular_component	RNA binding; cytosolic large ribosomal subunit (sensu Eukarya); cytosolic ribosome (sensu Eukarya); intracellular; protein biosynthesis; ribosome; ribosome biogenesis; structural constituent of ribosome
X82202	81767	ribosomal protein L19	cellular_component	RNA binding; cytosolic large ribosomal subunit (sensu Eukarya); intracellular; protein biosynthesis; ribosome; structural constituent of ribosome

Ribosome.

Uniqid	Locuslink	Gene name	Classification	Locuslink classifications
AC004263	6175	ribosomal protein, large, P0	cellular_component	RNA binding; cytosolic large ribosomal subunit (sensu Eukarya); intracellular; protein biosynthesis; ribosome; structural constituent of ribosome; translational elongation
AF083248	51121	ribosomal protein L26-like 1	cellular_component	intracellular; large ribosomal subunit; protein biosynthesis; structural constituent of ribosome
X06423	65136	ribosomal protein S8	cellular_component	RNA binding; cytosolic ribosome (sensu Eukarya); cytosolic small ribosomal subunit (sensu Eukarya); intracellular; protein biosynthesis; ribonucleoprotein complex; ribosome; ribosome biogenesis; structural constituent of ribosome
X80699	19941	ribosomal protein L26	cellular_component	RNA binding; cytosolic large ribosomal subunit (sensu Eukarya); cytosolic ribosome (sensu Eukarya); intracellular; protein biosynthesis; ribosome; ribosome biogenesis; structural constituent of ribosome
X82202	81767	ribosomal protein L19	cellular_component	RNA binding; cytosolic large ribosomal subunit (sensu Eukarya); intracellular; protein biosynthesis; ribosome; structural constituent of ribosome

Structural constituent of ribosome.

Uniqid	Locuslink	Gene name	Classification	Locuslink classifications
AC004263	6175	ribosomal protein, large, P0	molecular_function	RNA binding; cytosolic large ribosomal subunit (sensu Eukarya); intracellular; protein biosynthesis; ribosome; structural constituent of ribosome; translational elongation
AF083248	51121	ribosomal protein L26-like 1	molecular_function	intracellular; large ribosomal subunit; protein biosynthesis; structural constituent of ribosome
X06423	65136	ribosomal protein S8	molecular_function	RNA binding; cytosolic ribosome (sensu Eukarya); cytosolic small ribosomal subunit (sensu Eukarya); intracellular; protein biosynthesis; ribonucleoprotein complex; ribosome; ribosome biogenesis; structural constituent of ribosome
X80699	19941	ribosomal protein L26	molecular_function	RNA binding; cytosolic large ribosomal subunit (sensu Eukarya); cytosolic ribosome (sensu Eukarya); intracellular; protein biosynthesis; ribosome; ribosome biogenesis; structural constituent of ribosome
X82202	81767	ribosomal protein L19	molecular_function	RNA binding; cytosolic large ribosomal subunit (sensu Eukarya); intracellular; protein biosynthesis; ribosome; structural constituent of ribosome

Cytoplasm.

Uniqid	Locuslink	Gene name	Classification	Locuslink classifications
AB055804	5204	prefoldin 5	cellular_component	chaperone activity; nucleus; prefoldin complex; protein folding; regulation of transcription, DNA-dependent; transcription corepressor activity
AC004263	6175	ribosomal protein, large, P0	cellular_component	RNA binding; cytosolic large ribosomal subunit (sensu Eukarya); intracellular; protein biosynthesis; ribosome; structural constituent of ribosome; translational elongation
AF083248	51121	ribosomal protein L26-like 1	cellular_component	intracellular; large ribosomal subunit; protein biosynthesis; structural constituent of ribosome
AL050366	8473	O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine: polypeptide-N-acetylglucosaminyl transferase)	cellular_component	O-linked glycosylation; acetylglucosaminyltransferase activity; cytosol; nucleus; protein binding; response to nutrients; signal transduction; transferase activity, transferring glycosyl groups
AL110183	522	ATP synthase, H+ transporting, mitochondrial F0 complex, subunit F6	cellular_component	energy pathways; hydrogen ion transporter activity; membrane fraction; mitochondrial inner membrane; mitochondrion; proton transport; transporter activity
BC005936	55967	13 kDa differentiation-associated protein	cellular_component	NADH dehydrogenase (ubiquinone) activity; NADH dehydrogenase activity; mitochondrion; oxidoreductase activity; respiratory gaseous exchange
BC009677	93974	ATPase inhibitory factor 1	cellular_component	energy pathways; enzyme inhibitor activity; mitochondrion
BC012035	7095	translocation protein 1	cellular_component	cotranslational membrane targeting; endoplasmic reticulum; integral to membrane; protein transport; protein transporter activity; receptor activity
BC013873	1069	centrin, EF-hand protein, 2	cellular_component	calcium ion binding; centrosome; cytokinesis; mitosis
BC015766	87	actinin, alpha 1	cellular_component	actin binding; actin cytoskeleton; calcium ion binding; structural constituent of cytoskeleton
BC017448	9158	fibroblast growth factor (acidic) intracellular binding protein	cellular_component	fibroblast growth factor binding; fibroblast growth factor receptor signaling pathway; membrane fraction; mitochondrion; nucleus; protein binding
D10755	29673	proteasome (prosome, macropain) subunit, alpha type 6	cellular_component	RNA binding; cytosol; endopeptidase activity; hydrolase activity; peptidase activity; proteasome core complex (sensu Eukarya); ubiquitin-dependent protein catabolism
D87666	3320	heat shock 90 kDa protein 1, alpha	cellular_component	ATP binding; biological_process unknown; cellular_component unknown; chaperone activity; cytoplasm; heat shock protein activity; molecular_function unknown; protein folding
M25246	7431	vimentin	cellular_component	cytoplasm; intermediate filament; protein binding; structural constituent of cytoskeleton
X06423	65136	ribosomal protein S8	cellular_component	RNA binding; cytosolic ribosome (sensu Eukarya); cytosolic small ribosomal subunit (sensu Eukarya); intracellular; protein biosynthesis; ribonucleoprotein complex; ribosome; ribosome biogenesis; structural constituent of ribosome
X80699	19941	ribosomal protein L26	cellular_component	RNA binding; cytosolic large ribosomal subunit (sensu Eukarya); cytosolic ribosome (sensu Eukarya); intracellular; protein biosynthesis; ribosome; ribosome biogenesis; structural constituent of ribosome
X82202	81767	ribosomal protein L19	cellular_component	RNA binding; cytosolic large ribosomal subunit (sensu Eukarya); intracellular; protein biosynthesis; ribosome; structural constituent of ribosome
Y00672	7175	translocated promoter region (to activated MET oncogene)	cellular_component	cytoplasm; nuclear pore; nucleus; protein-nucleus import; transport

Structural molecule activity.

Uniqid	Locuslink	Gene name	Classification	Locuslink classifications
AC004263	6175	ribosomal protein, large, P0	molecular_function	RNA binding; cytosolic large ribosomal subunit (sensu Eukarya); intracellular; protein biosynthesis; ribosome; structural constituent of ribosome; translational elongation
AF083248	51121	ribosomal protein L26-like 1	molecular_function	intracellular; large ribosomal subunit; protein biosynthesis; structural constituent of ribosome
BC015766	87	actinin, alpha 1	molecular_function	actin binding; actin cytoskeleton; calcium ion binding; structural constituent of cytoskeleton
M25246	7431	vimentin	molecular_function	cytoplasm; intermediate filament; protein binding; structural constituent of cytoskeleton
X06423	65136	ribosomal protein S8	molecular_function	RNA binding; cytosolic ribosome (sensu Eukarya); cytosolic small ribosomal subunit (sensu Eukarya); intracellular; protein biosynthesis; ribonucleoprotein complex; ribosome; ribosome biogenesis; structural constituent of ribosome
X80699	19941	ribosomal protein L26	molecular_function	RNA binding; cytosolic large ribosomal subunit (sensu Eukarya); cytosolic ribosome (sensu Eukarya); intracellular; protein biosynthesis; ribosome; ribosome biogenesis; structural constituent of ribosome
X82202	81767	ribosomal protein L19	molecular_function	RNA binding; cytosolic large ribosomal subunit (sensu Eukarya); intracellular; protein biosynthesis; ribosome; structural constituent of ribosome

Cytosolic large ribosomal subunit (sensu Eukarya).

Uniqid	Locuslink	Gene name	Classification	Locuslink classifications
AC004263	6175	ribosomal protein, large, P0	cellular_component	RNA binding; cytosolic large ribosomal subunit (sensu Eukarya); intracellular; protein biosynthesis; ribosome; structural constituent of ribosome; translational elongation
X80699	19941	ribosomal protein L26	cellular_component	RNA binding; cytosolic large ribosomal subunit (sensu Eukarya); cytosolic ribosome (sensu Eukarya); intracellular; protein biosynthesis; ribosome; ribosome biogenesis; structural constituent of ribosome
X82202	81767	ribosomal protein L19	cellular_component	RNA binding; cytosolic large ribosomal subunit (sensu Eukarya); intracellular; protein biosynthesis; ribosome; structural constituent of ribosome

Protein binding.

Uniqid	Locuslink	Gene name	Classification	Locuslink classifications
AB055804	5204	prefoldin 5	molecular_function	chaperone activity; nucleus; prefoldin complex; protein folding; regulation of transcription, DNA-dependent; transcription corepressor activity
AK093927	5534	protein phosphatase 3 (formerly 2B), regulatory subunit B, 19kDa, alpha isoform (calcineurin B, type I)	molecular_function	biological_process unknown; calcineurin complex; calcium ion binding; calcium-dependent protein serine/threonine phosphatase activity; calmodulin inhibitor activity
AL050366	8473	O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)	molecular_function	O-linked glycosylation; acetylglucosaminyltransferase activity; cytosol; nucleus; protein binding; response to nutrients; signal transduction; transferase activity, transferring glycosyl groups
BC001062	65987	potassium channel tetramerisation domain containing 14	molecular_function	membrane; potassium ion transport; protein binding; voltage-gated potassium channel activity; voltage-gated potassium channel complex
BC015766	87	actinin, alpha 1	molecular_function	actin binding; actin cytoskeleton; calcium ion binding; structural constituent of cytoskeleton
BC017201	3490	insulin-like growth factor binding protein 7	molecular_function	extracellular; insulin-like growth factor binding; negative regulation of cell proliferation; regulation of cell growth
BC017245	11047	adhesion regulating molecule 1	molecular_function	cell adhesion; integral to plasma membrane; membrane fraction; protein binding
BC017448	9158	fibroblast growth factor (acidic) intracellular binding protein	molecular_function	fibroblast growth factor binding; fibroblast growth factor receptor signaling pathway; membrane fraction; mitochondrion; nucleus; protein binding
L11369	5097	protocadherin 1 (cadherin-like 1)	molecular_function	calcium ion binding; cell adhesion; cell-cell signaling; homophilic cell adhesion; integral to plasma membrane; intercellular junction; membrane; neurogenesis; protein binding
M25246	7431	vimentin	molecular_function	cytoplasm; intermediate filament; protein binding; structural constituent of cytoskeleton

Chromatin modification.

Uniqid	Locuslink	Gene name	Classification	Locuslink classifications
BC024391	20922	suppressor of Ty 4 homolog (S. cerevisiae)	biological_process	chromatin remodeling; nucleus; regulation of transcription from Pol II promoter; regulation of transcription, DNA-dependent; transcription; transcription factor activity
BC024391	20923	suppressor of Ty 4 homolog 2 (S. cerevisiae)	biological_process	chromatin remodeling; nucleus; regulation of transcription from Pol II promoter; regulation of transcription, DNA-dependent; transcription; transcription factor activity
X86691	1108	chromodomain helicase DNA binding protein 4	biological_process	ATP binding; ATP-dependent DNA helicase activity; chromatin; chromatin assembly/disassembly; chromatin binding; chromatin modification; chromosome organization and biogenesis (sensu Eukarya); nucleus; regulation of transcription from Pol II promoter; zinc ion binding

Protein biosynthesis.

Uniqid	Locuslink	Gene name	Classification	Locuslink classifications
AC004263	6175	ribosomal protein, large, P0	biological_process	RNA binding; cytosolic large ribosomal subunit (sensu Eukarya); intracellular; protein biosynthesis; ribosome; structural constituent of ribosome; translational elongation
AF083248	51121	ribosomal protein L26-like 1	biological_process	intracellular; large ribosomal subunit; protein biosynthesis; structural constituent of ribosome
AL050366	8473	O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)	biological_process	O-linked glycosylation; acetylglucosaminyltransferase activity; cytosol; nucleus; protein binding; response to nutrients; signal transduction; transferase activity, transferring glycosyl groups
X06423	65136	ribosomal protein S8	biological_process	RNA binding; cytosolic ribosome (sensu Eukarya); cytosolic small ribosomal subunit (sensu Eukarya); intracellular; protein biosynthesis; ribonucleoprotein complex; ribosome; ribosome biogenesis; structural constituent of ribosome
X80699	19941	ribosomal protein L26	biological_process	RNA binding; cytosolic large ribosomal subunit (sensu Eukarya); cytosolic ribosome (sensu Eukarya); intracellular; protein biosynthesis; ribosome; ribosome biogenesis; structural constituent of ribosome
X82202	81767	ribosomal protein L19	biological_process	RNA binding; cytosolic large ribosomal subunit (sensu Eukarya); intracellular; protein biosynthesis; ribosome; structural constituent of ribosome

Protein metabolism.

Uniqid	Locuslink	Gene name	Classification	Locuslink classifications
AB055804	5204	prefoldin 5	biological_process	chaperone activity; nucleus; prefoldin complex; protein folding; regulation of transcription, DNA-dependent; transcription corepressor activity
AC004263	6175	ribosomal protein, large, P0	biological_process	RNA binding; cytosolic large ribosomal subunit (sensu Eukarya); intracellular; protein biosynthesis; ribosome; structural constituent of ribosome; translational elongation
AF083248	51121	ribosomal protein L26-like 1	biological_process	intracellular; large ribosomal subunit; protein biosynthesis; structural constituent of ribosome
AF083420	8428	serine/threonine kinase 24 (STE20 homolog, yeast)	biological_process	ATP binding; protein amino acid phosphorylation; protein serine/threonine kinase activity; protein-tyrosine kinase activity; signal transduction; transferase activity
AL050366	8473	O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylgluco samine:polypeptide-N-acetylglucosaminyl transferase)	biological_process	O-linked glycosylation; acetylglucosaminyltransferase activity; cytosol; nucleus; protein binding; response to nutrients; signal transduction; transferase activity, transferring glycosyl groups
BC012035	7095	translocation protein 1	biological_process	cotranslational membrane targeting; endoplasmic reticulum; integral to membrane; protein transport; protein transporter activity; receptor activity
D10755	29673	proteasome (prosome, macropain) subunit, alpha type 6	biological_process	RNA binding; cytosol; endopeptidase activity; hydrolase activity; peptidase activity; proteasome core complex (sensu Eukarya); ubiquitin-dependent protein catabolism
D87666	3320	heat shock 90 kDa protein 1, alpha	biological_process	ATP binding; biological_process unknown; cellular_component unknown; chaperone activity; cytoplasm; heat shock protein activity; molecular_function unknown; protein folding
X06423	65136	ribosomal protein S8	biological_process	RNA binding; cytosolic ribosome (sensu Eukarya); cytosolic small ribosomal subunit (sensu Eukarya); intracellular; protein biosynthesis; ribonucleoprotein complex; ribosome; ribosome biogenesis; structural constituent of ribosome
X80699	19941	ribosomal protein L26	biological_process	RNA binding; cytosolic large ribosomal subunit (sensu Eukarya); cytosolic ribosome (sensu Eukarya); intracellular; protein biosynthesis; ribosome; ribosome biogenesis; structural constituent of ribosome
X82202	81767	ribosomal protein L19	biological_process	RNA binding; cytosolic large ribosomal subunit (sensu Eukarya); intracellular; protein biosynthesis; ribosome; structural constituent of ribosome
Y00672	7175	translocated promoter region (to activated MET oncogene)	biological_process	cytoplasm; nuclear pore; nucleus; protein-nucleus import; transport

Cell fraction.

Uniqid	Locuslink	Gene name	Classification	Locuslink classifications
AL110183	522	ATP synthase, H+ transporting, mitochondrial F0 complex, subunit F6	cellular_component	energy pathways; hydrogen ion transporter activity; membrane fraction; mitochondrial inner membrane; mitochondrion; proton transport; transporter activity
AY055759	1604	decay accelerating factor for complement (CD55, Cromer blood group system)	cellular_component	complement activation, classical pathway; integral to plasma membrane; membrane; soluble fraction
BC017245	11047	adhesion regulating molecule 1	cellular_component	cell adhesion; integral to plasma membrane; membrane fraction; protein binding
BC017448	9158	fibroblast growth factor (acidic) intracellular binding protein	cellular_component	fibroblast growth factor binding; fibroblast growth factor receptor signaling pathway; membrane fraction; mitochondrion; nucleus; protein binding
X92689	2591	UDP-N-acetyl-alpha-D-galactosamine polypeptide N-acetylgalactosaminyltransferase 3 (GalNAc-T3)	cellular_component	carbohydrate metabolism; integral to membrane; membrane fraction; polypeptide N-acetylgalactosaminyltransferase activity; transferase activity

DNA packaging.

Uniqid	Locuslink	Gene name	Classification	Locuslink classifications
BC024391	20922	suppressor of Ty 4 homolog (S. cerevisiae)	biological_process	chromatin remodeling; nucleus; regulation of transcription from Pol II promoter; regulation of transcription, DNA-dependent; transcription; transcription factor activity
BC024391	20923	suppressor of Ty 4 homolog 2 (S. cerevisiae)	biological_process	chromatin remodeling; nucleus; regulation of transcription from Pol II promoter; regulation of transcription, DNA-dependent; transcription; transcription factor activity
X86691	1108	chromodomain helicase DNA binding protein 4	biological_process	ATP binding; ATP-dependent DNA helicase activity; chromatin; chromatin assembly/disassembly; chromatin binding; chromatin modification; chromosome organization and biogenesis (sensu Eukarya); nucleus; regulation of transcription from Pol II promoter; zinc ion binding

Chromosome organization and biogenesis (sensu Eukarya).

Uniqid	Locuslink	Gene name	Classification	Locuslink classifications
BC024391	20922	suppressor of Ty 4 homolog (S. cerevisiae)	biological_process	chromatin remodeling; nucleus; regulation of transcription from Pol II promoter; regulation of transcription, DNA-dependent; transcription; transcription factor activity
BC024391	20923	suppressor of Ty 4 homolog 2 (S. cerevisiae)	biological_process	chromatin remodeling; nucleus; regulation of transcription from Pol II promoter; regulation of transcription, DNA-dependent; transcription; transcription factor activity
X86691	1108	chromodomain helicase DNA binding protein 4	biological_process	ATP binding; ATP-dependent DNA helicase activity; chromatin; chromatin assembly/disassembly; chromatin binding; chromatin modification; chromosome organization and biogenesis (sensu Eukarya); nucleus; regulation of transcription from Pol II promoter; zinc ion binding

Establishment and/or maintenance of chromatin architecture.

Uniqid	Locuslink	Gene name	Classification	Locuslink classifications
BC024391	20922	suppressor of Ty 4 homolog (S. cerevisiae)	biological_process	chromatin remodeling; nucleus; regulation of transcription from Pol II promoter; regulation of transcription, DNA-dependent; transcription; transcription factor activity
BC024391	20923	suppressor of Ty 4 homolog 2 (S. cerevisiae)	biological_process	chromatin remodeling; nucleus; regulation of transcription from Pol II promoter; regulation of transcription, DNA-dependent; transcription; transcription factor activity
X86691	1108	chromodomain helicase DNA binding protein 4	biological_process	ATP binding; ATP-dependent DNA helicase activity; chromatin; chromatin assembly/disassembly; chromatin binding; chromatin modification; chromosome organization and biogenesis (sensu Eukarya); nucleus; regulation of transcription from Pol II promoter; zinc ion binding

Nuclear organization and biogenesis.

Uniqid	Locuslink	Gene name	Classification	Locuslink classifications
BC024391	20922	suppressor of Ty 4 homolog (S. cerevisiae)	biological_process	chromatin remodeling; nucleus; regulation of transcription from Pol II promoter; regulation of transcription, DNA-dependent; transcription; transcription factor activity
BC024391	20923	suppressor of Ty 4 homolog 2 (S. cerevisiae)	biological_process	chromatin remodeling; nucleus; regulation of transcription from Pol II promoter; regulation of transcription, DNA-dependent; transcription; transcription factor activity
X86691	1108	chromodomain helicase DNA binding protein 4	biological_process	ATP binding; ATP-dependent DNA helicase activity; chromatin; chromatin assembly/disassembly; chromatin binding; chromatin modification; chromosome organization and biogenesis (sensu Eukarya); nucleus; regulation of transcription from Pol II promoter; zinc ion binding

Ribonucleoprotein complex.

Uniqid	Locuslink	Gene name	Classification	Locuslink classifications
AC004263	6175	ribosomal protein, large, P0	cellular_component	RNA binding; cytosolic large ribosomal subunit (sensu Eukarya); intracellular; protein biosynthesis; ribosome; structural constituent of ribosome; translational elongation
AF083248	51121	ribosomal protein L26-like 1	cellular_component	intracellular; large ribosomal subunit; protein biosynthesis; structural constituent of ribosome
X06423	65136	ribosomal protein S8	cellular_component	RNA binding; cytosolic ribosome (sensu Eukarya); cytosolic small ribosomal subunit (sensu Eukarya); intracellular; protein biosynthesis; ribonucleoprotein complex; ribosome; ribosome biogenesis; structural constituent of ribosome
X80699	19941	ribosomal protein L26	cellular_component	RNA binding; cytosolic large ribosomal subunit (sensu Eukarya); cytosolic ribosome (sensu Eukarya); intracellular; protein biosynthesis; ribosome; ribosome biogenesis; structural constituent of ribosome
X82202	81767	ribosomal protein L19	cellular_component	RNA binding; cytosolic large ribosomal subunit (sensu Eukarya); intracellular; protein biosynthesis; ribosome; structural constituent of ribosome

Calcium ion binding.

Uniqid	Locuslink	Gene name	Classification	Locuslink classifications
AK093927	5534	protein phosphatase 3 (formerly 2B), regulatory subunit B, 19 kDa, alpha isoform (calcineurin B, type I)	molecular_function	biological_process unknown; calcineurin complex; calcium ion binding; calcium- dependent protein serine/threonine phosphatase activity; calmodulin inhibitor activity
BC013873	1069	centrin, EF-hand protein, 2	molecular_function	calcium ion binding; centrosome; cytokinesis; mitosis
BC015766	87	actinin, alpha 1	molecular_function	actin binding; actin cytoskeleton; calcium ion binding; structural constituent of cytoskeleton
L11369	5097	protocadherin 1 (cadherin-like 1)	molecular_function	calcium ion binding; cell adhesion; cell-cell signaling; homophilic cell adhesion; integral to plasma membrane; intercellular junction; membrane; neurogenesis; protein binding

Regulation of transcription from Pol II promoter.

Uniqid	Locuslink	Gene name	Classification	Locuslink classifications
BC024391	20922	suppressor of Ty 4 homolog (S. cerevisiae)	biological_process	chromatin remodeling; nucleus; regulation of transcription from Pol II promoter; regulation of transcription, DNA-dependent; transcription; transcription factor activity
BC024391	20923	suppressor of Ty 4 homolog 2 (S. cerevisiae)	biological_process	chromatin remodeling; nucleus; regulation of transcription from Pol II promoter; regulation of transcription, DNA-dependent; transcription; transcription factor activity
X86691	1108	chromodomain helicase DNA binding protein 4	biological_process	ATP binding; ATP-dependent DNA helicase activity; chromatin; chromatin assembly/disassembly; chromatin binding; chromatin modification; chromosome organization and biogenesis (sensu Eukarya); nucleus; regulation of transcription from Pol II promoter; zinc ion binding

Chaperone activity.

Uniqid	Locuslink	Gene name	Classification	Locuslink classifications
AB055804	5204	prefoldin 5	molecular_function	chaperone activity; nucleus; prefoldin complex; protein folding; regulation of transcription, DNA-dependent; transcription corepressor activity
D87666	3320	heat shock 90 kDa protein 1, alpha	molecular_function	ATP binding; biological_process unknown; cellular_component unknown; chaperone activity; cytoplasm; heat shock protein activity; molecular_function unknown; protein folding
U10149	3306	heat shock 70 kDa protein 2	molecular_function	ATP binding; heat shock protein activity; male meiosis; spermatid development