Figures & data
Figure 1. Absence of a correlation between radiation sensitivity and heat sensitivity. Panel A shows a cross-correlation of radiation sensitivity, expressed as the dose of X-ray required to kill 90% of the cells, with heat sensitivity, expressed as the equivalent time of heating at 44°C required to kill 90% of the cells, in 30 different mouse cell lines derived from the literature. Panel B shows the comparison of heat sensitivity between various radiosensitive mutants (deficient in either non-homologous end-joining or in homologous recombination) and their isogenic repair proficient counterparts. The average sensitivity of the groups (indicated by the single points with error bars) is not different, nor is there a trend for increase or decrease in heat sensitivity in matched panels (indicated by the lines).
Figure 2. Reaction cycle of the Hsp70 chaperone machine and its regulation by cofactors.
Figure 3. Hypothetical model for cell death expression after hyperthermia. See text for explanation of the details.
Figure 4. Hypothetical model for the mechanism of heat-induced radiosensitization and the putative repair pathways involved.
