Preparation of carboplatin-Fe@C-loaded chitosan nanoparticles and study on hyperthermia combined with pharmacotherapy for liver cancer

Figures & data

Figure 1. (A) TEM of Fe@C nanopowder, (B) Fe@C nanocage, and (C) Carboplatin-Fe@C-loaded chitosan nanoparticles.

Figure 2. The time–temperature relationship curve in carboplatin-Fe@C-loaded chitosan nanoparticles of different concentrations.

Figure 3. The time–temperature relationship curve of carboplatin-Fe@C-loaded chitosan nanoparticles under different current strengths.

Figure 4. The time–temperature relationship curve in tumor and other sites in group D.

Table I.  The biochemical indicator levels in rat serum of each group after administration (x ± s).

Group	ALT (IU/L)	AST (IU/L)	TP (g/L)	ALB (g/L)	Cr (µmol/L)	BUN (µmol/L)
A	37.8 ± 6.7	106.2 ± 22.8	55.3 ± 6.5	25.8 ± 4.4	73.7 ± 11.4	7.1 ± 1.7
B	41.6 ± 7.2	105.4 ± 31.8	51.7 ± 7.9	23.5 ± 3.7	79.2 ± 9.7	7.6 ± 1.4
C	40.2 ± 8.5	97.3 ± 25.7	56.4 ± 7.2	26.7 ± 4.6	76.6 ± 8.3	7.3 ± 2.1
D	40.8 ± 6.2	126.3 ± 27.4	58.7 ± 8.3	28.4 ± 6.7	74.7 ± 10.3	7.1 ± 2.2

Note: The biochemical indicators in groups B, C and D are compared with group A.

Table II.  Tumor average weight and inhibition ratio of tumor weight in each group 7 days after treatment.

Group	Average weight (mg)	Inhibition ratio of tumor weight (%)
A	853.3 ± 121.2	0
B	780.3 ± 112.2	8.6
C	439.5 ± 77.2	48.5*
D	59.5 ± 15.2	93.0*^▴

Note: *Groups C and D compared with groups A and B, P < 0.01; ^▴Group D compared with group C, P < 0.01.

Figure 5. The survival curve of rats with transplanted liver cancer in each group.