Pediatric Asthmatic Patients Have Low Serum Levels of Monocyte Chemoattractant Protein-1

Abstract

Serum levels of MCP-1 were measured in children with and without asthma in order to determine a possible correlation between the MCP-1-2518A/G polymorphism, serum levels of MCP-1 and asthma. Two groups of subjects −160 children with asthma and 158 healthy children were screened with a PCR-based genotyping assay. Serum MCP-1 level was measured by ELISA. The -2518G allele occurred at a significantly higher frequency in asthmatic children than in controls. The mean serum MCP-1 level was significantly lower in the asthmatic than in the control children. There was no significant association between the MCP-1 genotypes and the serum MCP-1 levels.

Keywords:

• chemokines
• asthma
• atopy
• polymorphism
• endogenous cortisol
• inhaled corticosteroid
• inflammation
• MCP-1