Figures & data
Tables I and Table II. Overview of studies addressing associations between genetic alterations and clinical normal tissue radiosensitivity. Table I provides a list of studies with a particular focus on single nucleotide polymorphisms. The studies listed in Table II investigated other types of genetic variants or screened the genes for various sequence alterations.
Table I.
Angele S, Romestaing P, Moullan N, Vuillaume M, Chapot B, Eriesen M, et al. ATM haplotypes and cellular response to DNA damage: association with breast cancer risk and clinical radiosensitivity. Cancer Res 2003; 63: 8717–25 Andreassen, CN, Overgaard, J, Alsner, J, Overgaard, M, Herskind, C, Cesaretti, JA, et al. ATM sequence variants and risk of radiation induced subcutaneous fibrosis after post-mastectomy radiotherapy. In press, Int J Radiat Oncol Biol Phys. Moullan N, Cox DG, Angele S, Romestaing P, Gerard JP, Hall J. Polymorphisms in the DNA repair gene XRCC1, breast cancer risk, and response to radiotherapy. Cancer Epidemiol Biomarkers Prev 2003; 12: 1168–74 De Ruyck K, Van Eijkeren M, Claes K, Morthier R, De Paepe A, Vral A, et al. Radiation-induced damage to normal tissues after radiotherapy in patients treated for gynecologic tumors: Association with single nucleotide polymorphisms in XRCC1, XRCC3, and OGG1 genes and in vitro chromosomal radiosensitivity in lymphocytes. Int J Radiat Oncol Biol Phys 2005; 62: 1140–9 Chang-Claude J, Popanda O, Tan XL, Kroop S, Helmbold I, von Fournier D, et al. Association between polymorphisms in the DNA repair genes, XRCC1, APE1, and XPD and acute side effects of radiotherapy in breast cancer patients. Clin Cancer Res 2005; 11: 4802–9 Quarmby S, Fakhoury H, Levine E, Barber J, Wylie J, Hajeer AH, et al. Association of transforming growth factor beta-1 single nucleotide polymorphisms with radiation-induced damage to normal tissues in breast cancer patients. Int J Radiat Biol 2003; 79: 137–43 Andreassen CN, Alsner J, Overgaard M, Overgaard J. Prediction of normal tissue radiosensitivity from polymorphisms in candidate genes. Radiother Oncol 2003; 69: 127–35 Andreassen CN, Alsner J, Overgaard J, Herskind C, Haviland J, Owen R, et al. TGFB1 polymorphisms are associated with risk of late normal tissue complications in the breast after radiotherapy for early breast cancer. Radiother Oncol 2005; 75: 18–21 De Ruyck, K, Van Eijkeren, M, Claes, K, Vral, A, De Neve, W, Thierens, H. Association of single nucleotide polymorphisms in TGFb1 with late radiation induced damage to normal tissues in patients treated with radiotherapy for gynaecological tumors, Meetings abstract # W30,. 35th Annual Meting of the European Environmental Mutagen Society (2005). Green H, Ross G, Peacock J, Owen R, Yarnold J, Houlston R. Variation in the manganese superoxide dismutase gene (SOD2) is not a major cause of radiotherapy complications in breast cancer patients. Radiother Oncol 2002; 63: 213–6 Kornguth DG, Garden AS, Zheng Y, Dahlstrom KR, Wei Q, Sturgis EM. Gastrostomy in oropharyngeal cancer patients with ERCC4 (XPF) germline variants. Int J Radiat Oncol Biol Phys 2005; 62: 665–71 Appleby JM, Barber JB, Levine E, Varley JM, Taylor AM, Stankovic T, et al. Absence of mutations in the ATM gene in breast cancer patients with severe responses to radiotherapy. Br J Cancer 1997; 76: 1546–9 Clarke RA, Goozee GR, Birrell G, Fang ZM, Hasnain H, Lavin M, et al. Absence of ATM truncations in patients with severe acute radiation reactions. Int J Radiat Oncol Biol Phys 1998; 41: 1021–7 Ramsay J, Birrell G, Lavin M. Testing for mutations of the ataxia telangiectasia gene in radiosensitive breast cancer patients. Radiother Oncol 1998; 47: 125–8 Weissberg JB, Huang DD, Swift M. Radiosensitivity of normal tissues in ataxia-telangiectasia heterozygotes. Int J Radiat Oncol Biol Phys 1998; 42: 1133–6 Shayeghi M, Seal S, Regan J, Collins N, Barfoot R, Rahman N, et al. Heterozygosity for mutations in the ataxia telangiectasia gene is not a major cause of radiotherapy complications in breast cancer patients. Br J Cancer 1998; 78: 922–7 Hall EJ, Schiff PB, Hanks GE, Brenner DJ, Russo J, Chen J, et al. A preliminary report: frequency of A-T heterozygotes among prostate cancer patients with severe late responses to radiation therapy. Cancer J Sci Am 1998; 4: 385–9 Oppitz U, Bernthaler U, Schindler D, Sobeck A, Hoehn H, Platzer M, et al. Sequence analysis of the ATM gene in 20 patients with RTOG grade 3 or 4 acute and/or late tissue radiation side effects. Int J Radiat Oncol Biol Phys 1999; 44: 981–8 Iannuzzi CM, Atencio DP, Green S, Stock RG, Rosenstein BS. ATM mutations in female breast cancer patients predict for an increase in radiation-induced late effects. Int J Radiat Oncol Biol Phys 2002; 52: 606–13 Cesaretti JA, Stock RG, Lehrer S, Atencio DA, Bernstein JL, Stone NN, et al. ATM sequence variants are predictive of adverse radiotherapy response among patients treated for prostate cancer. Int J Radiat Oncol Biol Phys 2005; 61: 196–202 Bremer M, Klopper K, Yamini P, Bendix-Waltes R, Dork T, Karstens JH. Clinical radiosensitivity in breast cancer patients carrying pathogenic ATM gene mutations: no observation of increased radiation-induced acute or late effects. Radiother Oncol 2003; 69: 155–60 Borgmann K, Roper B, El Awady R, Brackrock S, Bigalke M, Dork T, et al. Indicators of late normal tissue response after radiotherapy for head and neck cancer: fibroblasts, lymphocytes, genetics, DNA repair, and chromosome aberrations. Radiother Oncol 2002; 64: 141–52 Gaffney DK, Brohet RM, Lewis CM, Holden JA, Buys SS, Neuhausen SL, et al. Response to radiation therapy and prognosis in breast cancer patients with BRCA1 and BRCA2 mutations. Radiother Oncol 1998; 47: 129–36 Pierce LJ, Strawderman M, Narod SA, Oliviotto I, Eisen A, Dawson L, et al. Effect of radiotherapy after breast-conserving treatment in women with breast cancer and germline BRCA1/2 mutations. J Clin Oncol 2000; 18: 3360–9 Leong T, Whitty J, Keilar M, Mifsud S, Ramsay J, Birrell G, et al. Mutation analysis of BRCA1 and BRCA2 cancer predisposition genes in radiation hypersensitive cancer patients. Int J Radiat Oncol Biol Phys 2000; 48: 959–65 Severin DM, Leong T, Cassidy B, Elsaleh H, Peters L, Venter D, et al. Novel DNA sequence variants in the hHR21 DNA repair gene in radiosensitive cancer patients. Int J Radiat Oncol Biol Phys 2001; 50: 1323–31 Price EA, Bourne SL, Radbourne R, Lawton PA, Lamerdin J, Thompson LH, et al. Rare microsatellite polymorphisms in the DNA repair genes XRCC1, XRCC3 and XRCC5 associated with cancer in patients of varying radiosensitivity. Somat Cell Mol Genet 1997; 23: 237–47 Andreassen CN, Alsner J, Overgaard J. Does variability in normal tissue reactions after radiotherapy have a genetic basis–where and how to look for it?. Radiother Oncol 2002; 64: 131–40