Visual outcome, local tumour control, and eye preservation after ¹⁰⁶Ru/Rh brachytherapy for choroidal melanoma

Figures & data

Figure 1.  Presentation of the preoperative and last measured postoperative visual acuity after ¹⁰⁶Ru/Rh brachytherapy. Eyes enucleated were set at no light perception. Visual acuity is shown in Snellen fractions except CF: counting fingers, HM: hand movements, +LP: light perception, -LP: no light perception.

Figure 2.  Probability for visual acuity retention after ¹⁰⁶Ru/Rh brachytherapy.

Table I.  Risk of vision loss for different parameters evaluated by univariate Cox proportional hazards analysis. Calculations were made for those eyes that had the possibility for a specific vision loss.

	Loss of 5 Snellen lines or more				Visual acuity loss to less than 0.33 if preoperative vision 0.33 or better				Visual acuity loss to 0.1 or less if preoperative vision better than 0.1
	n (events)	p	Rate ratio	95% CI	n (events)	p	Rate ratio	95% CI	n (events)	p	Rate ratio	95% CI
Age		0.16				0.64				0.93
≤ 60 years (reference)	22 (14)				17 (12)				22 (15)
> 60 years	23 (9)		0.55	0.24–1.27	17 (14)		1.21	0.55–2.65	23 (15)		0.97	0.46–2.03
Anterior tumour margin		0.30				0.53				0.13
Posterior to equator (ref)	30 (16)				22 (18)				30 (21)
Equator to ora serrata	15 (7)		1.63	0.65–4.12	12 (8)		1.33	0.55–3.19	15 (9)		1.92	0.83–4.43
Largest basal diameter		0.03				0.98				0.02
≤ 12 mm (ref.)	23 (9)				18 (14)				23 (14)
> 12 mm	22 (14)		2.53	1.09–5.91	16 (12)		0.99	0.45–2.19	22 (16)		2.45	1.15–5.20
Height		0.045				0.12				0.02
≤ 6 mm (ref.)	25 (11)				19 (15)				25 (16)
> 6 mm	19 (11)		2.48	1.02–6.01	15 (11)		1.93	0.84–4.47	19 (13)		2.66	1.17–6.06
Distance optic disc/fovea		0.81				0.13				0.56
> 2 mm (ref.)	23 (10)				17 (11)				23 (12)
≤ 2 mm	20 (11)		1.11	0.47–2.63	15 (13)		1.95	0.83–4.56	20 (16)		1.26	0.59–2.71
Local recurrence		<0.001				0.01				<0.001
No (ref)	30 (9)				21 (13)				30 (16)
Yes	15 (14)		10.09	3.90–26.11	13 (13)		3.21	1.43–7.20	15 (14)		4.94	2.24 –10.86
Preoperative visual acuity		0.01				0.29				0.47
Better than 6/12 (ref)	25 (17)				25 (18)				25 (17)
6/12 or worse	20 (6)		0.26	0.10–0.68	9 (8)		1.60	0.68–3.79	20 (13)		0.76	0.36–1.60

Figure 3.  Probability for no local recurrence and no enucleation after ¹⁰⁶Ru/Rh brachytherapy.

Figure 4.  Relation between local tumour control and tumour largest basal diameter and height after ¹⁰⁶Ru/Rh brachytherapy. For one tumour no information on largest basal diameter was available and for another no information on height.

Table II.  Risk of local recurrence and enucleation for reasons for different parameters evaluated by univariate Cox regression analysis.

	Local recurrence				Enucleation (all reasons)
	n (events)	p	Rate ratio	95% CI	n (events)	p	Rate ratio	95% CI
Age		0.18				0.08
≤ 60 years (reference)	27 (10)				27 (14)
> 60 years	28 (5)		0.48	0.16–1.40	28 (6)		0.42	0.16–1.10
Anterior tumour margin		0.01				0.04
Posterior to equator (ref)	37 (7)				37 (12)
Equator to ora serrata	18 (8)		3.64	1.30–10.26	18 (8)		2.72	1.07–6.93
Largest basal diameter		0.01				0.002
≤ 12 mm (ref.)	28 (4)				28 (5)
> 12 mm	26 (11)		4.33	1.37–13.65	26 (14)		5.11	1.83–14.29
Height		0.07				0.047
≤ 6 mm (ref.)	30 (6)				30 (8)
> 6 mm	24 (9)		2.60	0.92–7.35	24 (11)		2.53	1.01–6.31
Height		0.01				0.01
≤ 8 mm (ref.)	44 (10)				44 (13)
> 8 mm	10 (5)		4.06	1.37–11.99	10 (6)		3.87	1.45–10.31
Distance optic disc/fovea		0.60				0.79
> 2 mm (ref.)	25 (7)				25 (8)
≤ 2 mm	26 (7)		0.76	0.26–2.16	26 (10)		0.88	0.35–2.26