Concurrent chemoradiation therapy with low-dose CDDP and UFT for glottic carcinomas: Evaluation using the sixth edition of the UICC TNM staging system

Figures & data

Table I.  Characteristics of patients treated by the RT and CRT protocols.

Treatment protocol	RT	CRT	Total
No. of patients	49	51	100
Entry	retrospective	prospective
Treatment years	1989–1998	1999–2003
Mean age	67 (43–93)	62 (37–78)	65 (37–93)
Male: Female	48:1	47:4	95:5
UICC sixth edition
T2	27	27	54
T3	22	24	46

RT; radiation therapy alone, CRT; chemoradiation therapy.

Figure 1.  Curves for local control rates based on both treatment protocol and UICC 6^th edition T staging. RT; radiation therapy alone, CRT; chemoradiation therapy

Figure 2.  Curves for laryngeal preservation rates based on both treatment protocol and UICC 6^th edition T staging. RT; radiation therapy alone, CRT; chemoradiation therapy

Table II.  Five-year local control and laryngeal preservation rates by treatment protocol and UICC 6^th edition T staging.

Prognostic factors	Treatment protocol RT/CRT	UICC 6^th edition T2/T3	Total
No. of patients	49/51	54/46	100
5-year local control rate (%)	61/79	87/50	70
p-value	0.0965	<0.0001
5-year laryngeal preservation rate (%)	68/90	94/61	79
p-value	0.0135	<0.0001

RT; radiation therapy alone, CRT; chemoradiation therapy.

Table III.  Comparison of treatment effects (RT vs. CRT) on tumors staged according to the UICC 6^th edition.

T stage	T2 RT/CRT	T3 RT/CRT
No. of patients	27/27	22/24
5-year local control rate (%)	83/93	36/62
p-value	0.4875	0.0882
5-year laryngeal preservation rate (%)	92/96	40/83
p-value	0.5548	0.0063

RT; radiation therapy alone, CRT; chemoradiation therapy.