Differences in outcome for positive margins in a large cohort of breast cancer patients treated with breast-conserving therapy

Figures & data

Table I.  Distribution of the different clinical, pathohistological, and treatment characteristics for the 2 291 breast-conserving treatments in 2 223 breast cancer patients, according to margin status for invasive carcinoma (IC) and ductal carcinoma in situ (DCIS).

Characteristics	Negative Margin n = 1 985 (%)	Positive Margin IC n = 198 (%)	Positive Margin DCIS n = 108 (%)	p-value
Age
≤ 40 years	141 (7.1)	14 (7.1)	10 (9.3)	ns
> 40 years	1 844 (92.9)	184 (992.9)	98 (90.7)
Family history
positive	452 (22.8)	52 (26.3)	19 (17.6)	ns
negative	1 521 (76.6)	146 (73.7)	88 (81.5)
unknown	12 (0.6)		1 (0.9)
Localisation primary
lateral	1 270 (64)	127 (64.1)	86 (79.6)
medial	616 (31)	62 (31.3)	20 (18.5)	p = 0.023
central	99 (5)	9 (4.6)	2 (1.9)
Histology
ductal carcinoma	1 522 (76.7)	142 (71.7)	102 (94.4)	p < 0.001
lobular carcinoma	223 (11.2)	43 (21.7)	1 (0.9)
tubular carcinoma	150 (7.6)	7 (3.5)	2 (1.8)
medullar carcinoma	43 (2.7)	2 (1)	1 (0.9)
rest	47 (2.4)	4 (2.1)	2 (1.8)
Lymph-angioinvasion
positive	150 (7.6)	29 (16.7)	18 (16.7)
negative	1 797 (90.5)	162 (81.8)	86 (79.6)	p < 0.001
unknown	39 (1.9)	7 (3.5)	4 (3.7)
Oestrogen receptor
positive	1 393 (70.2)	149 (75.2)	69 (63.9)
negative	337 (17)	29 (14.7)	25 (23.2)	ns
unknown	255 (12.8)	20 (10.1)	14 (12.9)
Progesterone receptor
positive	1 173 (59.1)	116 (58.6)	57 (52.8)
negative	545 (27.5)	61 (30.8)	37 (34.3)	ns
unknown	267 (13.4)	21 (10.6)	14 (12.9)
Presence of CIS
DCIS	386 (19.4)	25 (12.6)	108
LCIS	122 (6.2)	18 (9.1)
none	1 477 (74.4)	155 (78.3)
Re-excision
yes	137 (6.9)	6 (3.0)	6 (5.5)
none	1 780 (89.7)	181 (91.4)	95 (88)	ns
unknown	68 (3.4)	11 (5.6)	7 (6.5)
Tumour size
pT1	1 555 (78.3)	129 (65.1)	89 (82.4)
pT2	420 (21.2)	69 (34.9)	19 (17.6)	p < 0.001
rest	10 (0.5)	0	0
Lymph nodes
pN0	1 432 (72.1)	126 (63.6)	60 (55.6)
pN1	514 (25.9)	65 (32.8)	44 (40.7)	p = 0.001
rest	39 (2.0)	7 (3.6)	4 (3.7)
Adjuvant Systemic Therapy
yes	657 (33.1)	83 (41.9)	58 (53.7)
none	1 328 (66.9)	115 (58.1)	50 (46.3)	p < 0.001
Adjuvant Radiotherapy
yes	411 (20.7)	49 (24.7)	39 (36.1)
none	1 574 (79.3)	149 (75.3)	69 (63.9)	p < 0.001

Figure 1.  The local relapse-free survival in 165 breast-conserving treatments according to margin status for women ≤40 years.

Figure 2.  The local relapse-free survival in 2 126 breast-conserving treatments according to margin status for women >40 years.

Figure 3.  The disease specific survival in 159 patients with 165 BCT according to margin status for women ≤40 years.

Figure 4.  The disease specific survival in 2 064 patients according to margin status for women >40 years.