Amplification of TOP2A and HER-2 genes in breast cancers occurring in patients harbouring BRCA1 germline mutations

Anne I. Hagen Department of Circulation and Medical Imaging, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway; Department of Surgery, St. Olav's Hospital, Trondheim University Hospital, N-7006, Trondheim, Norway

Anna M. Bofin Department of Laboratory Medicine, Children's and Women's Health, Faculty of Medicine, Norwegian University of Science and Technology, N-7006, Trondheim, Norway

Borgny Ytterhus Department of Laboratory Medicine, Children's and Women's Health, Faculty of Medicine, Norwegian University of Science and Technology, N-7006, Trondheim, Norway

Lovise O. Mæhle Section of Genetic Counselling, Norwegian Radium Hospital, N-0310, Oslo, Norway

Kjell H. Kjellevold Department of Pathology, Stavanger University Hospital, N-4068, Stavanger, Norway

Hans O. Myhre Department of Circulation and Medical Imaging, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway; Department of Surgery, St. Olav's Hospital, Trondheim University Hospital, N-7006, Trondheim, Norway

Pål Møller Section of Genetic Counselling, Norwegian Radium Hospital, N-0310, Oslo, Norway

Per E. Lønning Section of Oncology, Department of Medicine, Haukeland University Hospital, N-5021, Bergen, NorwayCorrespondence[email protected]

show all

Figures & data

Table I. Characteristics of cases and controls.

Download CSV Display Table

Figure 1a. FISH analysis of cancer cells showing HER-2 amplification without TOP2A amplification and four CEP 17. Red signals = TOP2A, green signals = HER-2, aqua signals = CEP 17.

Figure 1b. FISH analysis of cancer cells showing HER-2 and TOP2A coamplification. There are three CEP 17 (aqua) and greater than ten signals for both HER-2 (green) and TOP2A (red) genes. Genes to chromosome ratio >3.

Table II. HER-2/TOP2A findings.

Download CSV Display Table

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Amplification of TOP2A and HER-2 genes in breast cancers occurring in patients harbouring BRCA1 germline mutations

Table I. Characteristics of cases and controls.

Table II. HER-2/TOP2A findings.

Information for

Open access

Opportunities

Help and information

Your download is now in progress and you may close this window

Login or register to access this feature

Amplification of TOP2A and HER-2 genes in breast cancers occurring in patients harbouring BRCA1 germline mutations

Figures & data

Table I. Characteristics of cases and controls.

Table II. HER-2/TOP2A findings.

Reprints and Corporate Permissions

Academic Permissions

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date