Aniokis, a form of apoptosis or programmed cell death, triggered by loss of anchorage to the exracellular matrix (ECM). The peripheral cells adhere to the ECM proteins present in the growth media by integrins, whereas the central cells undergo anoikis due to lack of anchorage. This is demonstrated by activation of caspase 3, a protein in the apoptotic cascade. Figure 9.21.
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